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Blood dehydroepiandrosterone sulphate (DHEAS) levels in polymyalgia rheumatica/giant cell arteritis & primary fibromyalgia (FM)

  [ 20 votes ]   [ Discuss This Article ] • July 2, 1994

Blood levels of dehydroepiandrosterone sulphate (DHEAS) were
measured by radioimmunoassay (RIA) in patients with: a)
polymyalgia rheumatica/giant cell arteritis (PMR:TA; N = 25),
with and without cortisone derivative treatment (N = 10 and N
= 15, respectively); and b) primary fibromyalgia (PF; N = 15).

The mean DHEAS levels were found to be significantly
reduced in PMR:TA, compared to those in PF [FM] (Geom. mean
820 vs. 2300 nmol/l, respectively; p < 0.001), and the
reduction was more marked in patients on cortisone derivative
treatment. The DHEAS levels found in PF were found to be
normal and consistent with those previously reported in
non-immune mediated rheumatological diseases such as
osteoarthritis, and in healthy subjects, using the same method
of analysis. The low levels found in patients with PM:TA are
in accordance with those previously reported in
immune-mediated diseases such as systemic lupus erythematosus
(SLE) and rheumatoid arthritis, suggesting that diminution of
DHEAS is a constant endocrinologic feature in these categories
of patients. The pathophysiological significance of these low
DHEAS levels needs to be investigated.

Nilsson E, de la Torre B, Hedman M, Goobar J, Thorner A

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