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Dysregulated expression of tumor necrosis factor in Chronic Fatigue Syndrome (CFS): interrelations with cellular sources & patterns of soluble immune mediator expression

  [ 31 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 3, 1994


Among a group of 70 individuals who met the criteria
established by the Centers for Disease Control and Prevention
(Atlanta) for chronic fatigue syndrome (CFS), 12%-28% had
serum levels exceeding 95% of control values for tumor
necrosis factor (TNF) alpha, TNF-beta, interleukin (IL) 1
alpha, IL-2, soluble IL-2 receptor (sIL-2R), or neopterin;
overall, 60% of patients had elevated levels of one or more of
the nine soluble immune mediators tested. Nevertheless, only
the distributions for circulating levels of TNF-alpha and
TNF-beta differed significantly in the two populations. In
patients with CFS--but not in controls--serum levels of
TNF-alpha, IL-1 alpha, IL-4, and sIL-2R correlated
significantly with one another and (in the 10 cases analyzed)
with relative amounts (as compared to beta-globin or
beta-actin) of the only mRNAs detectable by reverse
transcriptase-coupled polymerase chain reaction in
peripheral-blood mononuclear cells: TNF-beta, unspliced and
spliced; IL-1 beta, lymphocyte fraction; and IL-6 (in order of
appearance). These findings point to polycellular activation
and may be relevant to the etiology and nosology of CFS.

Patarca R, Klimas NG, Lugtendorf S, Antoni M, Fletcher MA




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