ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Give Your Health a Much-Needed Boost With Geranium

The Role of Resveratrol in Achieving Optimal Health

Could Coconut Oil Help Reduce Antibiotics?

 
Print Page
Email Article

Dysregulated expression of tumor necrosis factor in Chronic Fatigue Syndrome (CFS): interrelations with cellular sources & patterns of soluble immune mediator expression

  [ 31 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 3, 1994


Among a group of 70 individuals who met the criteria
established by the Centers for Disease Control and Prevention
(Atlanta) for chronic fatigue syndrome (CFS), 12%-28% had
serum levels exceeding 95% of control values for tumor
necrosis factor (TNF) alpha, TNF-beta, interleukin (IL) 1
alpha, IL-2, soluble IL-2 receptor (sIL-2R), or neopterin;
overall, 60% of patients had elevated levels of one or more of
the nine soluble immune mediators tested. Nevertheless, only
the distributions for circulating levels of TNF-alpha and
TNF-beta differed significantly in the two populations. In
patients with CFS--but not in controls--serum levels of
TNF-alpha, IL-1 alpha, IL-4, and sIL-2R correlated
significantly with one another and (in the 10 cases analyzed)
with relative amounts (as compared to beta-globin or
beta-actin) of the only mRNAs detectable by reverse
transcriptase-coupled polymerase chain reaction in
peripheral-blood mononuclear cells: TNF-beta, unspliced and
spliced; IL-1 beta, lymphocyte fraction; and IL-6 (in order of
appearance). These findings point to polycellular activation
and may be relevant to the etiology and nosology of CFS.

Patarca R, Klimas NG, Lugtendorf S, Antoni M, Fletcher MA




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Break Free From Fibromyalgia Break Free From Fibromyalgia
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map