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Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia (FM) syndrome

  [ 13 votes ]   [ Discuss This Article ] • November 3, 1994

OBJECTIVE. To measure, and seek clinical correlates with,
levels of substance P (SP) in the cerebrospinal fluid (CSF) of
fibromyalgia syndrome (FMS) patients.

patients and 30 normal control subjects was tested for SP by
radioimmunoassay. Clinical measures included tender point
examination and standardized questionnaires.

levels were 3-fold higher in FMS patients than in normal
controls (P < 0.001), but they correlated only weakly with
tenderness found on examination.

CONCLUSION. SP is significantly elevated in FMS CSF, but
other abnormalities must exist in FMS to more fully explain
the symptoms.

Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE,
Lopez Y, MacKillip F

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