ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

Probiotics improve cognition in Alzheimer's patients

The Onion: Cancer Fighter and Food Preserver

SURVEY RESULTS: Cognitive Impairment II

 
Print Page
Email Article

Controlled trials of therapy in fibromyalgia (FM) syndrome

  [ 19 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 3, 1994


Many different interventions have been studied in the therapy of
fibromyalgia syndrome (Tables 1 and 2). While most have been
effective, in general these trials have been short term.
Furthermore, important or substantial improvement, when it has
been assessed, occurs in only small proportions of patients.
Long-term, comparative trials of both efficacy and toxicity
are necessary. Trials such as these require large numbers of
patients (compared with placebo-controlled trials, which are
generally impractical in long-duration trials due to the large
numbers of dropouts in the placebo arm) and therefore are
expensive and difficult to accomplish. Two other approaches
offer potential solutions to the problem of adequate long-term
comparative trials: (a) N-of-1 trials and (b) meta-analysis.
N-of-1 trials have the advantage of random assignment,
double-blinding and multiple potential comparisons in the same
patient. Meta-analysis involves combining the results of
studies, which individually may have conflicting results and
lack adequate statistical power, to reach an overall result
with sufficient statistical power to make meaningful
conclusions, especially with respect to comparative efficacy.
Peluso and colleagues (1993) have performed a recent
meta-analysis of available therapies in fibromyalgia syndrome
and found that the effect-size (a standardized measure of the
efficacy of a given therapy) of several non-medication
therapies such as electroacupuncture exceeded that of
traditional medication therapies. Unfortunately, lack of
uniformity in the use of outcome measures across included
trials and the small numbers of comparable non-medication
trials makes definitive conclusions regarding relative
efficacy of therapies difficult. Nevertheless, application of
meta-analytic methods such as these should facilitate future
comparisons of different interventions. Ideally, future
clinical trials in fibromyalgia syndrome should employ the
same outcome measures to permit application of these methods.
Few trials have assessed improvement in functional status.
Functional status measures such as the HAQ (Fries et al.,
1980), the Fibromyalgia Impact Questionnaire (Burckhardt et
al, 1991) or similar instruments should be employed in future
studies of therapy in fibromyalgia. Given that individual
modalities appear to confer relatively modest benefit on
average. Combination approaches are reasonable, although
randomized, blinded trials to assess these approaches are
methodologically complex. Several preliminary studies which
have addressed this approach appear promising (see Chapter 12;
Goldenberg et al, 1993). Finally, no studies have yet assessed
the comparative cost-efficacy of available treatments.
Controlled trials which address the cost-efficacy of commonly
employed, but unproven treatments such as physiotherapy
chiropractic manipulation and injection techniques are
urgently needed.

Simms RW




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map