ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Meet the ProHealth Editors

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

More positive evidence for melatonin in breast cancer battle

Omega-3 shows promise as stroke treatment

 
Print Page
Email Article

Controlled trials of therapy in fibromyalgia (FM) syndrome

  [ 19 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 3, 1994


Many different interventions have been studied in the therapy of
fibromyalgia syndrome (Tables 1 and 2). While most have been
effective, in general these trials have been short term.
Furthermore, important or substantial improvement, when it has
been assessed, occurs in only small proportions of patients.
Long-term, comparative trials of both efficacy and toxicity
are necessary. Trials such as these require large numbers of
patients (compared with placebo-controlled trials, which are
generally impractical in long-duration trials due to the large
numbers of dropouts in the placebo arm) and therefore are
expensive and difficult to accomplish. Two other approaches
offer potential solutions to the problem of adequate long-term
comparative trials: (a) N-of-1 trials and (b) meta-analysis.
N-of-1 trials have the advantage of random assignment,
double-blinding and multiple potential comparisons in the same
patient. Meta-analysis involves combining the results of
studies, which individually may have conflicting results and
lack adequate statistical power, to reach an overall result
with sufficient statistical power to make meaningful
conclusions, especially with respect to comparative efficacy.
Peluso and colleagues (1993) have performed a recent
meta-analysis of available therapies in fibromyalgia syndrome
and found that the effect-size (a standardized measure of the
efficacy of a given therapy) of several non-medication
therapies such as electroacupuncture exceeded that of
traditional medication therapies. Unfortunately, lack of
uniformity in the use of outcome measures across included
trials and the small numbers of comparable non-medication
trials makes definitive conclusions regarding relative
efficacy of therapies difficult. Nevertheless, application of
meta-analytic methods such as these should facilitate future
comparisons of different interventions. Ideally, future
clinical trials in fibromyalgia syndrome should employ the
same outcome measures to permit application of these methods.
Few trials have assessed improvement in functional status.
Functional status measures such as the HAQ (Fries et al.,
1980), the Fibromyalgia Impact Questionnaire (Burckhardt et
al, 1991) or similar instruments should be employed in future
studies of therapy in fibromyalgia. Given that individual
modalities appear to confer relatively modest benefit on
average. Combination approaches are reasonable, although
randomized, blinded trials to assess these approaches are
methodologically complex. Several preliminary studies which
have addressed this approach appear promising (see Chapter 12;
Goldenberg et al, 1993). Finally, no studies have yet assessed
the comparative cost-efficacy of available treatments.
Controlled trials which address the cost-efficacy of commonly
employed, but unproven treatments such as physiotherapy
chiropractic manipulation and injection techniques are
urgently needed.

Simms RW




Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map