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Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) [Ampligen] in Chronic Fatigue Syndrome (CFS)

  [ 17 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 3, 1994


Latent 2', 5'-oligoadenylate (2-5A) synthetase activity,
bioactive 2-5A and RNase L activity were measured in extracts
of peripheral blood mononuclear cells (PMBC) before and during
a randomized, multicenter, placebo-controlled, double-blind
study of poly(I)-poly(C12U) in individuals with chronic
fatigue syndrome (CFS) as defined by the Centers for Disease
Control and Prevention. The mean values for bioactive 2-5A and
RNase L activity were significantly elevated at baseline
compared to controls (p < .0001 and p = .001, respectively).
In individuals that presented with elevated RNase L activity
at baseline, therapy with poly(I)-poly(C12U) resulted in a
significant decrease in both bioactive 2-5A and RNase L
activity (p = .09 and p = .005, respectively). Decrease in
RNase L activity in individuals treated with
poly(I)-poly(C12U) correlated with cognitive improvement (p =
.007). Poly(I)-poly(C12U) therapy resulted in a significant
decrease in bioactive 2-5A and RNase L activity in agreement
with clinical and neuropsychological improvements (Strayer DR,
et al., Clin. Infectious Dis. 18:588-595, 1994). The results
described show that poly(I)-poly(C12U) is a biologically
active drug in CFS.

Suhadolnik RJ, Reichenbach NL, Hitzges P, Adelson ME, Peterson DL,
Cheney P, Salvato P, Thompson C, Loveless M, Muller WE, et al




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