ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tea drinkers have lower glaucoma risk

Basic Aromatherapy to Help Balance and Calm

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Wonderful White Tea: A Drink Fit for an Emperor

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

 
Print Page
Email Article

Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with Chronic Fatigue Syndrome (CFS)

  [ 26 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 3, 1994


Levels of 2',5'-oligoadenylate (2-5A) synthetase, bioactive
2-5A, and RNase L were measured in extracts of peripheral
blood mononuclear cells (PBMCs) from 15 individuals with
chronic fatigue syndrome (CFS) before and during therapy with
the biological response modifier poly(I).poly(C12U) and were
compared with levels in healthy controls. Patients differed
significantly from controls in having a lower mean basal level
of latent 2-5A synthetase (P < .0001), a higher pretreatment
level of bioactive 2-5A (P = .002), and a higher level of
pretherapy RNase L activity (P < .0001). PBMC extracts from 10
persons with CFS had a mean basal level of activated 2-5A
synthetase higher than the corresponding control value (P =
.009). All seven pretherapy PBMC extracts tested were positive
for the replication of human herpesvirus 6 (HHV-6). Therapy
with poly(I).poly(C12U) resulted in a significant decrease in
HHV-6 activity (P < .01) and in downregulation of the 2-5A
synthetase/RNase L pathway in temporal association with
clinical and neuropsychological improvement. The upregulated
2-5A pathway in CFS before therapy is consistent with an
activated immune state and a role for persistent viral
infection in the pathogenesis of CFS. The response to therapy
suggests direct or indirect antiviral activity of
poly(I).poly(C12U) in this situation.

Suhadolnik RJ, Reichenbach NL, Hitzges P, Sobol RW, Peterson DL,
Henry B, Ablashi DV, Muller WE, Schroder HC, Carter WA, et al




Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™ Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map