ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Immunological abnormalities in patients with Chronic Fatigue Syndrome (CFS)

  [ 12 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 3, 1994


Between January 1991 and January 1993, 265 patients who
fulfilled the CDC criteria of the working case definition of
Chronic Fatigue Syndrome (CFS) have been observed at our
Institution and submitted for clinical and laboratory
evaluation. One hundred and sixty-three patients were females
and 102 males, the median age was 35 years (range 4-55 years);
all patients reported profound and prolonged fatigue, lasting
for a median of 3 years (range 6 months-10 years), preceded or
accompanied at appearance by fever in 185 cases, and
neuropsychologic problems including inability to concentrate,
difficulty in thinking, confusion, irritability,
forgetfulness, and depression. The fatigue was so severe that
it required 102 patients to stop their working activities for
a period of time ranging from 3 months to 2 years (range 7
months). In 40 consecutive patients a comprehensive
immunologic testing by single and two-colour flow cytometry
was performed and results compared with a group of 35 healthy,
age- and sex-matched controls.
Whilst no significant differences were found in the
absolute numbers of circulating total T cells (CD3+) and of
total helper/inducer (CD4+) or suppressor/cytotoxic (CD8+) T
cells, an evident reduction in CD3-/CD16+ and CD57+/CD56+ NK
lymphocytes along with an expansion of the CD8+/CD56+ and
CD16-/CD56+ NK subsets, were found in the CFS group. In
addition, CD56+ NK cells from CFS subjects were found to
express an increased amount of cell adhesion molecules (CD11b,
CD11c, CD54) and activation antigens (CD38). Both the
percentage and absolute numbers of CD4+ T cells bearing the
CD45RA antigen appeared significantly reduced in CFS patients,
and CD4+ T lymphocytes from CFS subjects displayed an
increased expression of the intercellular adhesion molecule-1
(ICAM-1/CD54). Finally, the total numbers of circulating
(CD19+) B lymphocytes, were significantly higher in CFS cases
than in controls, and in 11 out of 30 CFS patients the
increase in circulating B cells was sustained by the expansion
of the CD5+/CD19+ subset of B lymphocytes. We conclude that
CFS is a syndrome not previously described in Italy, with
already known clinical characteristics and appears to be
associated with several immunologic abnormalities, including
those reported previously in cohort of patients from different
countries. We also show for the first time that CD56- NK cell
subsets from CFS patients display an abnormally increased
expression of cell adhesion molecules and activation markers.

Tirelli U, Marotta G, Improta S, Pinto A




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map