ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

Can Pomegranates Slow Aging?

Calorie restriction promotes longevity through effects on mitochondrial network

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

How Can You Benefit From Vitamin B12?

Drug can dramatically reduce weight of people with obesity

What Is Bitter Orange?

 
Print Page
Email Article

Immunological abnormalities in patients with Chronic Fatigue Syndrome (CFS)

  [ 12 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 3, 1994


Between January 1991 and January 1993, 265 patients who
fulfilled the CDC criteria of the working case definition of
Chronic Fatigue Syndrome (CFS) have been observed at our
Institution and submitted for clinical and laboratory
evaluation. One hundred and sixty-three patients were females
and 102 males, the median age was 35 years (range 4-55 years);
all patients reported profound and prolonged fatigue, lasting
for a median of 3 years (range 6 months-10 years), preceded or
accompanied at appearance by fever in 185 cases, and
neuropsychologic problems including inability to concentrate,
difficulty in thinking, confusion, irritability,
forgetfulness, and depression. The fatigue was so severe that
it required 102 patients to stop their working activities for
a period of time ranging from 3 months to 2 years (range 7
months). In 40 consecutive patients a comprehensive
immunologic testing by single and two-colour flow cytometry
was performed and results compared with a group of 35 healthy,
age- and sex-matched controls.
Whilst no significant differences were found in the
absolute numbers of circulating total T cells (CD3+) and of
total helper/inducer (CD4+) or suppressor/cytotoxic (CD8+) T
cells, an evident reduction in CD3-/CD16+ and CD57+/CD56+ NK
lymphocytes along with an expansion of the CD8+/CD56+ and
CD16-/CD56+ NK subsets, were found in the CFS group. In
addition, CD56+ NK cells from CFS subjects were found to
express an increased amount of cell adhesion molecules (CD11b,
CD11c, CD54) and activation antigens (CD38). Both the
percentage and absolute numbers of CD4+ T cells bearing the
CD45RA antigen appeared significantly reduced in CFS patients,
and CD4+ T lymphocytes from CFS subjects displayed an
increased expression of the intercellular adhesion molecule-1
(ICAM-1/CD54). Finally, the total numbers of circulating
(CD19+) B lymphocytes, were significantly higher in CFS cases
than in controls, and in 11 out of 30 CFS patients the
increase in circulating B cells was sustained by the expansion
of the CD5+/CD19+ subset of B lymphocytes. We conclude that
CFS is a syndrome not previously described in Italy, with
already known clinical characteristics and appears to be
associated with several immunologic abnormalities, including
those reported previously in cohort of patients from different
countries. We also show for the first time that CD56- NK cell
subsets from CFS patients display an abnormally increased
expression of cell adhesion molecules and activation markers.

Tirelli U, Marotta G, Improta S, Pinto A




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Clinically Studied Joint Relief Product for FM & ME/CFS Clinically Studied Joint Relief Product for FM & ME/CFS
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map