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A double-blind placebo controlled trial of fluoxetine in fibromyalgia (FM)

  [ 137 votes ]   [ Discuss This Article ] • January 3, 1994

42 women were randomized to receive either placebo or fluoxetine at
20 mgs per day. Inter and intra group differences in clinical
variables were evaluated after 3 and 6 weeks of treatment.

Except for self rated anxiety which improved in the placebo
treated group at 3 weeks, no differences between groups were
noted. For those receiving fluoxetine both AIMS Anxiety (4.0
baseline vs. 3.3, p = 0.04) and Depression scores (2.6
baseline vs. 1.9, p = 0.03) improved at 3 weeks; however,
improvement in the Beck Depression Scale did not reach
significance (11.8 vs. 9.4, p = 0.34). At 6 weeks, both AIMS
Depression (2.6 at baseline and 1.5 at 6 weeks, p = 0.03) and
Beck Depression Scales (11.8 at baseline vs. 8.3 at 6 weeks, p
= 0.04) showed improvement, as did sleep quality (9.6 vs. 7.6,
p = 0.03). But no other variable had a significant change from
baseline at either the 3 or 6 week point.

Our data do not suggest that fluoxetine improves the
signs and symptoms of fibromyalgia.

Wolfe F, Cathey MA, Hawley DJ

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