ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Innocent bacteria may help IBS

  [ 21 votes ]   [ Discuss This Article ] • September 5, 2000

Certain normal bacteria within the gastrointestinal tract play an important part in the prevention of an unhealthy inflammatory immune response, and blocking this immune reaction could be crucial to stopping debilitating intestinal diseases in their tracks.

The findings, published in Science by a team of Emory University pathologists, have implications to those suffering from irritable bowel syndrome, a common complication of CFS. Until now scientists presumed these typical bacteria were simply ‘innocent wallflowers.’ The new findings show that these bacteria, known as normal flora, actually deliver a signal that blocks NF-kB - a genetic protein involved in activating genes in the immune system.

"It's interesting that the organisms we are studying are non-pathogenic (do not cause disease) and have no ability to elicit inflammation themselves, yet they are able to block inflammatory pathways and create tolerance for themselves and perhaps other organisms," said researcher Andrew Neish, M.D.

The gastrointestinal tract of humans and other vertebrates is home to a delicate bacterial balancing act in which a diverse ecosystem of non-pathogenic bacteria co-exist among potential pathogens, all under the watchful guard of protective immune cells.

Although the intestinal non-pathogenic bacteria, or normal flora, are known to play a biological role in enabling the breakdown of certain vitamins and other substances, scientists have generally believed these bacteria to be otherwise inert residents of the GI tract. The usually harmonious co-existence between intestinal organisms and immune cells dates back through millions of years of evolution, from the time of the earliest known vertebrates.

The Emory team of pathologists, including Neish, James Madara, M.D. and Andrew Gewirtz, Ph.D., and their colleagues, discovered that non-pathogenic bacteria in the G.I. tract are not merely the innocent intestinal wallflowers they were presumed to be, but that they actually deliver a signal that blocks an important immune-system pathway called NF-KB -- a transcription factor involved in activating genes in the immune system.

"It's fascinating that the epithelium (lining of the intestine) can tolerate the presence of this density of bacteria while also being quite permeable to nutrients and fluids," says Dr. Neish. "Almost all other tissue types in the body are exquisitely sensitive to bacteria and their products. Now we have found a mechanism by which non-pathogenic bacteria block the inflammatory pathway and prevent cells in the G.I tract from responding as any other cell would respond.

“This mechanism for tolerance also could be fundamental to the pathogenesis of inflammatory bowel disease (Crohn's disease and ulcerative colitis) and to other infectious intestinal diseases," he said.

Crohn's disease and ulcerative colitis are diseases in which individuals develop a chronic and debilitating intestinal inflammatory response. Inflammatory bowel disease is one of the last few major unexplained diseases, although scientists have long suspected that it is related to lack of tolerance to the community of intestinal organisms.

“There is a possibility that the balance of beneficial to non-beneficial bacteria is altered in these patients," explains Dr. Neish. "A genetic flaw in the epithelial lining of the G.I. tract could also cause an abnormal response to the non-pathogenic bacteria."

The discovery also may shed light on the growing field of probiotics, in which investigators are experimenting with various species of benign bacteria that can be ingested with foods, such as lacto-bacillus (found in yogurt), to improve the intestinal health of patients with inflammatory bowel disease. The Emory research could elucidate a potential mechanism for the positive effects of probiotics.

"It turns out that some non-pathogenic bacteria have a significant reciprocal ecological interaction with the host. The host can mount an immune response to control resident bacteria, but even non-pathogenic bacteria have an ability to influence that immune response," said Neish.

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3 Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map