ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

AMA journal associates iron deficiency with hearing loss

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

A Better Pain Reliever for Rheumatoid Arthritis

  [ 25 votes ]   [ Discuss This Article ]
By ArthritisSupport.com • www.ProHealth.com • April 12, 2000



A new kind of arthritis drug provides the same relief of pain and inflammation in people with rheumatoid arthritis as a typical nonsteroidal anti-inflammatory drug but with fewer ulcers and other gastrointestinal side effects, according to a 12-week study led by a researcher at Beth Israel Deaconess Medical Center in Boston.

In a randomized, placebo-controlled study of 1,149 people with rheumatoid arthritis, a new kind of drug known as a "COX-2 inhibitor" was as effective as a commonly prescribed nonsteroidal anti-inflammatory drug known as naproxen. Yet, only about 6 percent people taking COX-2 inhibitors developed ulcers compared to 26 percent of people taking an equivalent pain-relieving dose of naproxen. The ulcer rate of people on the COX-2 inhibitors was statistically similar to the 4 percent ulcer rate suffered by people in the placebo group.

The study is published in the Nov. 24 issue of the Journal of the American Medical Association. "As an advocate for patients with chronic inflammation or pain or both, I believe it is my responsibility to recommend COX-2 specific inhibitors because of their increased safety profile," says Beth Israel Deaconess rheumatologist Lee S. Simon MD, the lead author of the study, which was conducted at 79 hospitals, medical centers and private practices across the country.

Rheumatoid arthritis is one of the most serious and disabling types of arthritis, affecting more than 2.1 million people in this country, or about 1 percent of the population. An autoimmune disease that inflames the lining of the joints, rheumatoid arthritis causes pain, swelling, stiffness, and loss of function. For physicians and patients, managing the symptoms is an ongoing challenge, complicated by the occasional severe gastrointestinal side effects caused by long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), which are among the most commonly used medications in the world.

Bleeding ulcers pose the most serious gastrointestinal risk in people taking NSAIDs, says Simon, also an associate professor of medicine at Harvard Medical School. In general, younger NSAID users face a three times greater risk of ulcers and their complications than nonusers, while people older than 60 face an even higher risk.

Only about one in 1,000 ulcers are likely to develop potentially serious complications, but with 17 million daily users of NSAIDs the complication rate translates into about 170,000 serious cases a year. An estimated excess 7,500-15,000 gastrointestinal deaths related to toxicity of NSAIDs occur annually.

About 20 NSAIDs are available in this country, including aspirin, ibuprofen and acetaminophen, according to Simon. All NSAIDs inhibit both forms of an enzyme that plays an important role in the stomach, intestines and kidney. One form of the enzyme, known as COX-1, protects the lining of the gastrointestinal system. Inhibition of this enzyme is considered to be a major cause of the toxic effects of NSAIDs. However, COX-2 is the form of the enzyme involved in pain and inflammation.

In the past 12 months, two COX-2 inhibitors have been approved by the FDA with a promise of relieving symptoms with fewer dangerous side effects. In this study, researchers used celecoxib, marketed as Celebrex by Searle and approved in December 1998.

Another COX-2 inhibitor, rofecoxib (marketed as Vioxx by Merck), was approved in May. Citing a recent cluster of peer-reviewed papers with similar findings in studies of each drug, Simon believes the results of his study apply generally to COX-2 specific inhibitors.

"COX-2 inhibitors have been called 'super aspirins,' but they provide the same pain relief as NSAIDs," says Simon. "What makes them better for patients is increased gastrointestinal safety." Over the past 20 years, Simon has focused on the risks, benefits, actions and toxicities of NSAIDs.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Breaking Through the Mental Fog Breaking Through the Mental Fog
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map