ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

High levels of estrogen associated with breast cancer recurrence

  [ 245 votes ]   [ 1 Comment ]
By American Association for Cancer Research • www.ProHealth.com • March 6, 2008


Mar 6, PHILADELPHIA – Women whose breast cancer came back after treatment had almost twice as much estrogen in their blood than did women who remained cancer-free – despite treatment with anti-estrogen drugs in a majority of the women – according to researchers in a study published in the March issue of Cancer Epidemiology, Biomarkers and Prevention, a journal of the American Association for Cancer Research. [See footnote* to link to an abstract and free full text pdf of the article.]

The findings suggest that high levels of estrogen contribute to an increased risk of cancer recurrence, just as they lead to the initial development of breast cancer, said the study’s lead author, Cheryl L. Rock, PhD, a professor in the Department of Family and Preventive Medicine at the University of California, San Diego.

“While this makes sense, there have been only a few small studies that have looked at the link between sex hormones in the blood and cancer recurrence,” she said. “This is the largest study to date and the only one to have included women taking agents such as tamoxifen to reduce estrogen’s effect on cancer growth.

“What the results mean for women who have already been treated for breast cancer is that they should do as much as they can to reduce estrogen in their blood, such as exercising frequently and keeping weight down,” she added. “Taking anti-estrogen drugs like tamoxifen may not completely wipe out the hormone’s effect in women who have high levels of estrogen.”

Participants from this study were drawn from the larger Women’s Healthy Eating and Living Study (WHEL), a dietary intervention trial that followed 3,088 women who had been treated for early stage breast cancer but who were cancer-free at the time they enrolled.

Normal Healthy Diet ‘Sufficient’

Participants were randomly assigned to one of two groups:

  • One that ate a “normal” healthy diet,
  • And the other that ate extremely high amounts of fruits, fiber, and vegetables.
  • Both were followed for more than seven years.
  • Breast cancer recurrence was about the same in each group, according to the results, published in 2007. Researchers interpreted the findings to mean that a normal diet that incorporates the U.S. Food and Drug Administration guidelines for recommended amounts of fruits and vegetables is sufficient.

    In the current nested case-control study, 153 WHEL participants whose cancer had recurred were matched with 153 participants who remained cancer-free. These pairs were alike in terms of tumor type, body size, age, ethnicity, use of chemotherapy and other variables. Two-thirds of the participants were using tamoxifen, Rock said.

    When they enrolled, researchers tested the women’s blood for concentrations of the steroid hormones estradiol (the primary human estrogen) and testosterone. They analyzed different forms of estradiol and testosterone in the blood, such as how much was bound to transport proteins (such as to the sex hormone binding globulin, or SHBG) and how much was “free” circulating and able to enter a cell.

    Estrogen, Not Testosterone or SHBG, Predicted Recurrence

    Researchers found that higher estradiol concentrations, in all forms, significantly predicted cancer recurrence. Overall, women whose cancer came back had an average total estradiol concentration that was more than double the average for women who remained cancer-free.

    Increased levels of testosterone or SHBG levels were not associated with recurrence, contradicting the findings of several previous studies.

    Although genetic and metabolic factors likely influence the relationship between circulating sex hormones and risk of breast cancer recurrence, Rock said the study provides solid evidence that higher concentrations of estradiol in the blood contribute to risk for breast cancer recurrence.

    ___
    * For an abstract and free full-text pdf of the article - “Reproductive Steroid Hormones and Recurrence-Free Survival in Woman with a History of Breast Cancer” – go to http://www.prohealth.com/library/showarticle.cfm?id=2897&T=Health

    Note: This information has not been evaluated by the FDA. It is generic and is not meant to prevent, diagnose, treat or cure any illnes, condition, or diseae. It is very important that you make no change n your healthcare plan or health support regimen without researching and reviewing it in collaboration with your professional healthcare team.




    Post a Comment

    Featured Products From the ProHealth Store
    Ultra EPA  - Fish Oil Optimized Curcumin Longvida® Energy NADH™ 12.5mg

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products


    Article Comments Post a Comment

    Article: High levels of estrogen associated with breast cancer recurrence
    Posted by: JeNeSuisPersonne
    Mar 12, 2008
    Re: effect of diet - I'd be interested to know which women were consuming caseine (from milk products), and other animal proteins. Cancer growth/hinderance findings from The China Study indicate a strong possibility of being able to turn off cancer cell growth by avoiding animal protein, especially caseine. Hmmmm. . . might be worth looking into.
    Reply Reply
     
    NAD+ Ignite with Niagen

    Featured Products

    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid

    Natural Remedies

    How I Found My Long-Lost Energy How I Found My Long-Lost Energy
    Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
    Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
    SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
    D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map