ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Astaxanthin Is a Longevity Promoter

Meta-analysis links vitamin D deficiency with increased risk of mortality during 10.5 year median pe...

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Valerian Root Help You Sleep Better?

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

Fighting Statin-Induced Diabetes with CoQ10

 
Print Page
Email Article

Nrf2 activation by sulforaphane restores the age-related decrease of Th1 immunity: Role of dendritic cells – Source: Journal of Allergy and Clinical Immunology, Mar 6, 2008

  [ 159 votes ]   [ Discuss This Article ]
By Hyon-Jeen Kim, PhD, Andre E. Nel, MD, PhD, et al. • www.ProHealth.com • March 10, 2008


[Note: Nrf2 is a protein which serves as a “master regulator” of the body's overall antioxidant response and is capable of switching on hundreds of antioxidant and rejuvenating genes and enzymes. Th1 cells are “hormonal messengers responsible for most biological effects in the immune system.” Dendritic cells pick up antigens from the skin or mucous membranes & present them to the T cells.]

Background: The decrease in cellular immunity with aging is of considerable public health importance. Recent studies suggest that the redox [reduction/oxidation] equilibrium of dendritic cells (DCs) is a key factor in maintaining protective cellular immunity and that a disturbance of this homeostatic mechanism could contribute to immune senescence [aging].

Objectives: We sought:

1. To elucidate the role of DC redox equilibrium in the decrease of contact hypersensitivity (CHS) and Th1 immunity during aging, and

2. To determine how restoration of glutathione (GSH) levels by the Nrf2-mediated antioxidant defense pathway affects this decrease.

Methods: We assessed the effect of Nrf2 deficiency and boosting of GSH levels by the Nrf2 agonist sulforaphane or the thiol precursor N-acetyl cysteine (NAC) on the CHS response to contact antigens in old mice. We studied the effect of SFN and NAC on restoring Th1 immunity by treating DCs ex vivo before adoptive transfer and in vivo challenge.

Results: Aging was associated with a decreased CHS response that was accentuated by Nrf2 deficiency. Systemic SFN treatment reversed this decrease through Nrf2-mediated antioxidant enzyme expression and GSH synthesis. Adoptive transfer of DCs from old animals induced a weakened CHS response in recipient animals. Treatment of DCs from old animals with SFN or NAC ex vivo restored the in vivo challenge response.

Conclusion: SFN and NAC upregulate Th1 immunity in aging through a restoration of redox equilibrium. [For a plain-language interpretation of the study findings, see “UCLA study finds that broccoli may help boost the aging immune system.”]

Source: Journal of Allergy and Clinical Immunology, Mar 6, 2008. [E-pub ahead of print] PMID: 18325578, by kim HJ, Barajas B, Wang M, Nel AE. Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095 [E-mail: anel@mednet.ucla.edu]





Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map