ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Short-term and Long-term Safety of Weekly High-dose Vitamin D3 Supplementation in School Children – Source: The Journal of Clinical Endocrinology & Metabolism, April 29, 2008

  [ 295 votes ]   [ Discuss This Article ]
By J Maalouf, G El-Hajj Fuleihan, et al. • www.ProHealth.com • June 4, 2008


[The full text of this article is available free at http://jcem.endojournals.org/cgi/rapidpdf/jc.2007-2530v1]

Background: Hypovitaminosis D [insufficient vitamin D] is prevalent in youth worldwide, but the safety of vitamin D at doses exceeding 200 IU/day is unknown in this age group.

We assessed the safety of high doses of vitamin D3 administered to apparently healthy school children.

Methods:

  • Short term safety: 25 subjects randomly received placebo or vitamin D3 at doses of 14,000 IU/wk for 8 weeks.
  • Long term safety: 340 subjects randomly received placebo, vitamin D3 as 1400 IU or 14,000 IU/week for one year. [Note: 1,400 IU/wk is the current recommendation for this age group; 14,000 IU/wk is half the dose considered safe for adults]
  • Biochemical variables were monitored at 0, 2, 4, 6, 8 weeks, and 8 weeks off therapy in the short term study and at 0, 6 and 12 months in the long term study.

    Results:

    In both the short term and long term studies, mean serum calcium and 1,25-OHD levels did not change in any group.

    In the short term study, mean 25-OHD concentrations increased from 44 (+/- 11) ng/ml to 54 (+/- 19) ng/ml in the treated groups (P=0.033).

    In the long term study, mean 25-OHD levels increased from 15+/-8 to 19+/-7 ng/ml (p<0.0001) in subjects receiving 1400 IU/wk; and from 15+/-7 to 36+/-22ng/ml in the group receiving 14,000 IU/wk (p<0.0001).

    No subject developed vitamin D intoxication.

    Conclusion: Vitamin D3 at doses equivalent to 2,000 IU/day for one year is safe in adolescents and results in desirable vitamin D levels.

    Source: The Journal of Clinical Endocrinology & Metabolism, April 29, 2008. [Epub ahead of print] PMID: 18445674, by Maalouf J, Nabulsi M, Vieth R, Kimball S, El-Rassi R, Mahfoud Z, El-Hajj Fuleihan G. Schools of Medicine and Health Sciences, American University of Beirut, Lebanon; Department of Nutritional Sciences, University of Toronto, Canada. [E-mail: Ghada E-Hajj Fuleihan, MD, MPH gf01@aub.edu.1b]





    Post a Comment

    Featured Products From the ProHealth Store
    Ultra ATP+, Double Strength Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®

    Looking for Vitamins, Herbs and Supplements?
    Search the ProHealth Store for Hundreds of Natural Health Products


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    NAD+ Ignite with Niagen

    Featured Products

    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid
    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%

    Natural Remedies

    Complete and Natural Menopause Relief Complete and Natural Menopause Relief
    Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
    Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
    Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
    Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map