ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

16 Tips from 16 Years Sick

Fibromyalgia Fare Fit for All Seasons

New Study Shows Artificial Sweeteners Lead to Diabetes

Essential Oils — An Effective and Healthy Option to Treat Headaches

Higher vitamin D levels associated with less severe disease in NAFLD patients

Krill Oil: Make This Omega-3 Supplement Part of Your Health Regimen

How zinc helps fight esophageal cancer

Everything You Need to Know About Black Cohosh

Low vitamin D levels predict ED in diabetics

The Cellular Enzyme That Promotes Longevity And Reduces Fat Storage

 
Print Page
Email Article

Incidence of melanoma and other malignancies among rheumatoid arthritis patients treated with methotrexate - Source: Arthritis and Rheumatism, May 30, 2008

  [ 252 votes ]   [ Discuss This Article ]
By Rachelle Buchbinder, et al. • www.ProHealth.com • June 6, 2008


[Note: Methotrexate (Rheumatrex) has been one of the most effective and commonly used medicines to treat rheumatic conditions. Methotrexate interferes with several enzymes involved in the immune system and is known as a disease-modifying antirheumatic drug (DMARD) because it not only decreases the pain and swelling of arthritis but also can reduce damage to joints - according to information on the American College of Rheumatology website.]

Objective: To determine cancer risk in a cohort of 459 rheumatoid arthritis (RA) patients treated with methotrexate in community practice.

Methods:
All RA patients who started methotrexate prior to June 1986 and were attending 1 of 6 rheumatologists were studied.

Demographic data were matched to the State Cancer Registry to identify all malignancies (except nonmelanoma skin cancer) for 1983-1998, and to the National Death Index to identify all deaths to the end of 1999.

Follow-up started on the date when methotrexate was started and ended either on the last confirmed date on which the patient was seen by the rheumatologist or at death.

Standardized incidence ratios (SIRs) were calculated using state population cancer rates stratified by sex, age (in 5-year groups), and calendar year.

Results:
There were 4,145 person-years of follow-up (average 9.3 years).

Eighty-seven malignancies were identified (14 before, 64 during, and 9 after the followup period).

There was an estimated 50% excess risk of malignancy among methotrexate-exposed RA patients relative to the general population (SIR 1.5, 95% confidence interval [95% CI] 1.2-1.9), with:

  • A 3-fold increase in melanoma (SIR 3.0, 95% CI 1.2-6.2),
  • A 5-fold increase in non-Hodgkin's lymphoma (SIR 5.1, 95% CI 2.2-10.0),
  • And an almost 3-fold increase in lung cancer (SIR 2.9, 95% CI 1.6-4.8).
  • Conclusion:
    Compared with the general population, methotrexate-treated RA patients have an increased incidence of melanoma, non-Hodgkin's lymphoma, and lung cancer.

    There may be a role for regular skin cancer screening for all RA patients, particularly those receiving immunosuppressive therapy.

    Source: Arthritis and Rheumatism, May 30, 2008. 59(6):794-799. [E-pub ahead of print] PMID: 18512713, Buchbinder R, Barber M, Heuzenroeder L, Wluka AE, Giles G, Hall S, Harkness A, Lewis D, Littlejohn G, Miller MH, Ryan PF, Jolley D. Cabrini Hospital and Monash University, Melbourne, Victoria, Australia. [E-mail: Rachelle Buchbinder rachelle.buchbinder@med.monash.edu.au]





    Post a Comment

    Featured Products From the ProHealth Store
    Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™


    Article Comments



    Be the first to comment on this article!

    Post a Comment


     
    Optimized Curcumin Longvida with Omega-3

    Featured Products

    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid
    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Optimized Curcumin Longvida® Optimized Curcumin Longvida®
    Supports Cognition, Memory & Overall Health
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%

    Natural Remedies

    Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
    IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
    Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
    The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
    Breaking Through the Mental Fog Breaking Through the Mental Fog

    CONTACT US
    ProHealth, Inc.
    555 Maple Ave
    Carpinteria, CA 93013
    (800) 366-6056  |  Email

    · Become a Wholesaler
    · Vendor Inquiries
    · Affiliate Program
    SHOP WITH CONFIDENCE
    Credit Card Processing
    SUBSCRIBE TO OUR NEWSLETTERS
    Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

    CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

    © 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map