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California chemist on a mission to educate about CoQ10

  [ 222 votes ]   [ 1 Comment ] • July 24, 2008

"Nature gave us, through 2.5 billion years of evolution, a number of fundamental anti-aging, free-radical scavengers that helped us to survive…. Coenzyme Q10 is as important as vitamin C. But who’s teaching this to our aging population? Nobody.” - CoQ10 expert Bruce Lipshutz

Bruce Lipshutz, a professor of chemistry at the University of California, Santa Barbara, comments here on the "life-sustaining role" of CoQ10 - and his research group's recent breakthrough,* which may soon allow its delivery in a form the cells can drink in twice as efficiently.


Never heard of CoQ10? "If you don't know anything about it, that's not surprising to me,” Lipshutz said during a recent interview. “Much of the public hasn't heard of it.” But he's on a mission to correct what he views as a major oversight. "In a sense, I'm just a messenger. People need to not only know about CoQ10, they need to take it."

Like vitamin C, CoQ10 is a compound that's vital to our survival.

It's a coenzyme that our cells synthesize - albeit in 21 steps - and it's in every cell. This contrasts with a vitamin, such as vitamin C, which is not made by the body.

Both CoQ10 and vitamin C are "compounds of evolution," Lipshutz said. "Everybody accepts the importance of vitamin C. The reason the public does not fully appreciate it is that there's no Linus Pauling for CoQ10. There is no champion."

Pauling, a Nobel Prize-winning scientist, was also an advocate for greater consumption of vitamin C. "CoQ is not really in that category of public awareness yet," Lipshutz said.

While the body produces its own CoQ10, that production decreases with age.

"Nature gave us, through 2.5 billion years of evolution, a number of fundamental anti-aging, free-radical scavengers that helped us to survive, on average, only to about 40 years of age, until modern medicine came along," Lipshutz said.

A large percentage of the body is made up of water. "But there are also the lipophilic [affinity for lipids/fats] portions of our cells that make up the non-aqueous part," Lipshutz explained. At some point in our evolution, the water-soluble antioxidant vitamin C was produced in vivo [by the body] - or what would technically be "coenzyme C."

Eventually, "a mutation took place that now prevents humans from making vitamin C," he said. "However, evolution chose not to mutate out CoQ10."

If one doesn't get vitamin C, the consequences can be dire. "It's essential for several cellular processes. For example, everyone knows about scurvy," Lipshutz said. "You can last 30 days, maybe 60 days, as your cells deteriorate."

Essential for production of cellular fuel. On the other hand, CoQ10 - much of which is in the mitochondria of our cells - is essential for cellular respiration and production of ATP [adenosine triphosphate, the fuel the mitrochondria burn for energy]. "You wouldn't last 30 minutes without CoQ10," he said.

"Thus, evolution teaches us that CoQ10 is as important as vitamin C. But who's teaching this to our aging population? Nobody."

Lipshutz has a history of CoQ10 research at UCSB:

  • Initially, he retooled the chemistry that would produce the supplement via synthesis instead of fermentation, which is what Japan used to become the world leader in CoQ10 production.
  • But China's entry into the CoQ10 market only a few years ago changed everything. "The price of CoQ for over 30 years was about $1,600 per kilo as produced by the Japanese," Lipshutz said. "The Chinese came along and, for the time being, have dramatically altered the market by deciding at the government level that they were going to own this important area of dietary supplements. CoQ10 can now be purchased for as little as $400 a kilo, which in principle is great news for consumers."

When the supply of CoQ10 grew faster than demand, Lipshutz went into the lab to study what else could be done with this life-enriching compound.

After all, CoQ is now readily available. At [supplement and drug stores], you can buy CoQ10 formulated into softgels that deliver the nutrient in various strengths. It's marketed as helping to provide a boost in energy as well as a healthy heart.

But, Lipshutz notes, we can still absorb only 10 to 15 percent of CoQ10 in the softgel form. How, he asked, could this become more available and bioefficient?

"The future is not about access to CoQ10 anymore," he said. "It's not about, 'Do we have the best synthesis?' or 'Can we compete with the Chinese?' It's about getting it into water, so that we can get it into our mitochondria."

Quite a challenge, since CoQ10 is water insoluble. The answer? Go nano.

"We do it with nano-micelle-forming technology," Lipshutz said. He starts by putting a known, inexpensive molecule called PTS into water, which spontaneously forms a nanosphere about 25 nanometers (one nanometer is equal to one millionth of a millimeter) in diameter. This sphere has a lipophilic portion tied to a hydrophilic portion through a linker. The lipophilic portion, which is actually vitamin E, goes to the center. "The vitamin E portion associates in the middle with itself because it doesn't have any solubility, any energy-lowering interactions, with the water around it," Lipshutz said. "But the external or hydrophilic portion associates with water.

"So, on the outside is the water-loving portion, while the lipophilic, or grease-loving portion, is on the inside. When you add the CoQ, it says, 'Where would I rather be?' Since like dissolves like, the CoQ10 goes inside the micelle. It's 25 nanometers and it's crystal clear. And, it's stable at room temperature."

That's nanotechnology. It delivers twice the amount of the compound into the bloodstream, and the concentration in water can be adjusted, he said. This approach can be applied to a broad range of nutraceuticals, including omega-3s, carotenoids like lutein and beta-carotene, and resveratrol. "We can also take pharmaceuticals, like Taxol, an anti-tumor agent, and put them into just water or saline using this PTS," he said. * Reference: "Transition Metal Catalyzed Cross-Couplings Going Green: in Water at Room Temperature," Aldrichimica Acta, in Press, September 2008;41(3). Bruce Lipshutz, Subir Ghorai, et al. University of California, Santa Barbara.

Source: University of California, Santa Barbara

Note: This information has not been evaluated by the FDA. It is generic and is not meant to prevent, diagnose, treat or cure any illness, condition, or disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.

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Article Comments Post a Comment

Posted by: marta608
Jul 30, 2008
What's the bottom line here? Take Co Q-10 because we need it, or save our money because it isn't absorbed if we take it?
Reply Reply
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