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Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome – Source: Journal of Pharmacological Sciences, Jun 2008

  [ 87 votes ]   [ Discuss This Article ]
By Masaru Kunitomo, et al. • • July 25, 2008

[Full text of article free in pdf file.]

Metabolic syndrome (MetS) is a group of cardiovascular risk factors, including visceral obesity (fat around internal organs), glucose intolerance, hypertension, and dyslipidemia (unhealthy blood cholesterol).

Increased oxidative and nitrative stress and inflammation and decreased endothelial function occur in an animal model of metabolic syndrome, SHR/NDmcr-cp (SHR/cp) rats. [Endothelium is the lining of the blood vessels, and loss of proper endothelial function is "a hallmark" of many disorders.]

The present study investigated the effects of coenzyme Q10 (CoQ10), one of the important antioxidants, on the abnormal oxidative condition and characteristic components of metabolic syndrome in SHR/cp rats by maintaining them on a diet supplemented with 0.07% - 0.7% CoQ10 for 26 weeks.

We determined serum levels of oxidatively modified low-density lipoprotein (Ox-LDL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as oxidative stress markers, 3-nitrotyrosine as a nitrative stress marker, 3-chlorotyrosine as a marker of myeloperoxidase (MPO)-catalyzed oxidation and high-sensitivity C-reactive protein (hsCRP) as an inflammatory marker.

  • The administration of CoQ10 significantly attenuated the increase of oxidative and nitrative stress markers and inflammatory markers in a dose-dependent manner.
  • CoQ10 prevented the elevated serum insulin levels, although it did not affect the elevated glucose level and dyslipidemia.
  • CoQ10 also reduced elevated blood pressure, but did not affect body weight gain.
  • In addition, CoQ10 improved endothelial dysfunction in the mesenteric arteries.

These findings suggest that the antioxidant properties of CoQ10 can be effective for ameliorating cardiovascular risk in MetS.

Source: Journal of Pharmacological Sciences, Jun 2008; 107(2), pp. 128-137. PMID: 18544898, by kunitomo M, Yamaguchi Y, Kagota S, Otsubo K. School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan. [E-mail:]

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