ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Immune System’s Killer Cells Recognize Specific Viruses

  [ 26 votes ]   [ Discuss This Article ]
By xx • • May 9, 2001

Researchers have discovered that immune system cells called natural killer cells can recognize and destroy specific viruses. Scientists previously thought these cells responded to infection only in a nonspecific way. The findings are reported in the May 4 issue of Science.

"Understanding how natural killer cells eradicate virus-infected cells will help in the development of specific vaccines and treatments," says Wayne M. Yokoyama, M.D., a Howard Hughes Medical Institute Investigator and Professor of Medicine and Chief of Rheumatology at Washington University School of Medicine in St. Louis.

Natural killer cells were named for their ability to spontaneously kill cancer cells. As part of the body’s innate immunity, they also secrete a protein called interferon-gamma, which rallies the rest of the immune system against infected cells. By responding as soon as a damaged cell appears, natural killer cells defend the body while other immune cells are gearing up for action. Their radar system for detecting cells that need to be destroyed consists of a large array of related protein receptors. These activation receptors sit on the natural killer cell surface.

Scientists have suspected that natural killer cells might be able to respond in more specific ways than interferon secretion. For example, humans without natural killer cells are susceptible to only certain types of virus infections. Also, strains of mice that normally resist murine cytomegalovirus (MCMV) become susceptible when deprived of natural killer cells whereas other strains of mice are genetically susceptible. In previous work, the Yokoyama laboratory, in collaboration with a group led by Dr. Anthony Scalzo at the University of Western Australia, determined that a genetic locus, termed the NK gene complex, controlled resistance or susceptibility.

In their current work, the researchers found an unusual mouse that seemed to have the genes for resistance but the mice were susceptible. They showed that these mice had the usual complex of genes for highly related natural killer cell receptors, including a protein family called Ly-49. However, one member of that family was missing. It was a receptor called Ly-49H.

The group then inactivated the Ly-49H receptors of normal, MCMV-resistant mice by injecting an antibody that attaches only to Ly-49H protein. They injected other normal mice with an antibody that eliminates virtually all natural killer cells. When exposed to MCMV, the two groups of mice developed equally severe infections. So taking away Ly-49H was just as harmful as taking away the natural killer cells themselves.

"Without the Ly-49H receptor, the virus infection is rampant, and the mice die," Yokoyama says. "Our results suggest that natural killer cell receptors also play a role in specific defense against other infections."

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map