ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Novel Form of Vitamin D Shown to Grow Bone

  [ 23 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 1, 2002


MADISON - A novel form of vitamin D has been shown to grow bone in the lab and in experimental animals, a result that holds promise for the estimated 44 million Americans, mostly post-menopausal women, who suffer from or are at risk for the bone-wasting disease osteoporosis.

The research, conducted by a team of scientists led by biochemist Hector F. DeLuca at the University of Wisconsin-Madison, was reported this week (Sept. 30) in the Proceedings of the National Academy of Sciences (PNAS), a leading scientific journal.

"We've got a compound that is very selective for bone," says DeLuca. "It is very effective in animals," increasing bone density significantly in rats with a condition that mimics human osteoporosis, and can be used in the lab to grow bone in culture.

The research, conducted by DeLuca, Nirupama K. Shevde, Lori A. Plum, Margaret Claggett-Dame, Hironori Yamamoto and J. Wesley Pike, describes the effects of a potent Vitamin D analog known in scientific shorthand as 2MD. Its synthesis by the Wisconsin group, and studies of its effects in the lab and in animals, suggests the potential for developing a class of drugs that could effectively reverse bone loss in humans suffering from osteoporosis, a disease characterized by diminished bone density and, ultimately, brittle, fracture-prone bones.

"From where I sit, this is the most promising vitamin D compound I've seen," says DeLuca, an international authority on vitamin D and its chemistry.

But he stressed that while the new compound posts astonishing results when used in experimental animals, it has yet to be tested in humans and it will likely be several years at best before a drug reaches the market.

"There's nothing like it on the market now. We think it could become a major actor, but we haven't done any experiments in people," he says.

The compound could become an important alternative to hormone replacement therapy, one of whose benefits was prevention of bone loss in post-menopausal women. Because of new evidence of an increased risk of cancer, hormone replacement therapy has recently been called into question.

The vitamin D analog developed by the Wisconsin team was tested in rats that had their ovaries removed to mimic menopause and the bone wasting associated with osteoporosis. Rats given the new vitamin D analog exhibited a 9 percent increase in total body bone mass. Importantly, vertebrae in the treated rats exhibited a 25 percent increase in bone mass. Frequently, osteoporosis patients exhibit a stooped posture as the bones in the spinal column tend to be among the most affected by osteoporosis.

The compound also added bone mass to the long bones in the limbs of animals used in the study.

According to DeLuca, the 2MD compound is also the first vitamin D analog shown to increase bone mass, and that exhibits no apparent toxicity or side effects.

2MD acts at very low concentrations and appears to work by promoting the growth of osteoblasts, the cells responsible for making bone. Another form of vitamin D is now used to treat osteoporosis, but its bone-building action is limited.

"Our results suggest that 2MD exhibits at very low concentrations a marked and unexpected activity in stimulating the synthesis of new bone," the Wisconsin team wrote in their PNAS report. "This activity is at best only weakly observed with (the other active form of vitamin D) and then only at very high concentrations."

It is possible, the authors suggest, that 2MD possesses a "unique capacity to induce genes capable of orchestrating the process leading to the formation of bone nodules."



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Vitamin D3 Extreme™ Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map