ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Rhodiola — A Powerful Adaptogen That Boosts Vitality and Performance, Eases Depression and Combats B...

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

Vitamin D deficiency during pregnancy can program obesity in children

 
Print Page
Email Article

Abstract: Treatment of Fibromyalgia with Antidepressants: A Meta-Analysis

  [ 46 votes ]   [ Discuss This Article ]
By P.G. O'Malley, E. Balden, G. Tomkins, J. Santoro, K. Kroenke, J.L. Jackson • www.ProHealth.com • November 7, 2001



Competing interests: None declared

Funding: MacArthur Foundation Initiative on Depression in Primary Care. This digest and commentary appeared in Evidence-Based Medicine, 2001; 6:77

DATA SOURCES
Studies in any language were identified by searching MEDLINE (1966 to June 1999), PsycLIT (1974-1998), and EMBASE/Excerpta Medica (1974-1998) with the terms fibromyalgia, fibrositis, and fibromyositis combined with various terms for antidepressive agents (including specific drug names); the Cochrane Library Clinical Trials Registry and Database of Systematic Reviews; Federal Research in Progress to identify unpublished trials; and bibliographies of reviewed articles.

STUDY SELECTION
Studies were selected if they were randomized, placebo-controlled trials with at least 1 group receiving an antidepressant drug and if they reported measurable outcomes.

DATA EXTRACTION
Data were extracted on setting; country; dose, duration, and follow-up of treatment; number of participants and demographics; assessment of comorbid disease; follow-up losses (i.e., unavailable for follow-up); adverse effects; and outcomes. Methodologic quality of individual trials was assessed using the Jadad scale.

MAIN RESULTS
We included 13 trials (mean sample size, 54; mean duration, 8.1 weeks) in the analysis. Mean quality score for the Jadad scale was 5.6 of a maximum of 8. Nine studies did not give the method of randomization, 7 had no intention-to-treat analysis, 3 inadequately assured blinding effectiveness, 5 did not assess adverse effects, and 6 had lower than 20% loss to follow-up. Trials assessed the efficacy of 3 classes of antidepressant drugs: tricyclic antidepressants (8 trials of amitriptyline hydrochloride, 1 of clomipramine hydrochloride, and 1 of maprotiline hydrochloride), S-adenosyl-1-methionine (2 trials), and selective serotonin reuptake inhibitors (2 of fluoxetine hydrochloride and 1 of citalopram hydrobromide).

Meta-analysis was done using a random-effects model. Meta-analysis of dichotomous outcome data (10 trials) showed that patients who received antidepressants had more symptom improvement than those who received placebo (odds ratio, 4.2 [95% confidence interval (CI), 2.6-6.8]; number needed to treat, 4 [95% CI, 2.9-6.3]). Meta-analysis of continuous outcome data showed that antidepressant drugs were associated with improvements in fatigue scores (8 trials, 0.39 SD unit improvement [95% CI, 0.11-0.66]), sleep scores (8 trials, 0.49 SD unit improvement [95% CI, 0.3-0.69]), pain scores (10 trials, 0.52 SD unit improvement [95% CI, 0.21-0.81]), and overall well-being (7 trials, 0.49 SD unit improvement [95% CI, 0.18-0.80]) but not in the number of trigger points.

CONCLUSION
Antidepressant drugs improve overall symptoms and individual symptoms of fatigue, sleep, and pain in patients with fibromyalgia.




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Can Pomegranates Slow Aging? Can Pomegranates Slow Aging?
The Cellular Enzyme That Promotes Longevity And Reduces Fat Storage The Cellular Enzyme That Promotes Longevity And Reduces Fat Storage
A Hard-Working Molecule that May Help Ease Pain & Brighten Mood A Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Relief for Dry, Itchy Skin Caused by Fibromyalgia Relief for Dry, Itchy Skin Caused by Fibromyalgia

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map