ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

Give Your Health a Much-Needed Boost With Geranium

 
Print Page
Email Article

Abstract: FMRI Evaluation of Pain Intensity Coding in Fibromyalgia Patients and Controls

  [ 21 votes ]   [ Discuss This Article ]
By Masilo, AB, Grant, Michael, J., Farrell, Reshma, Kumar, Daniel J., Clauw, Richard H., Gracely • www.ProHealth.com • November 16, 2001




Aim: Tenderness is a defining attribute of fibromyalgia (FM). Using functional MRI (fMRI) imaging in previous studies, we found evidence that tenderness in FM results from a central augmentation of pain perception. This study used fMRI to evaluate a new cohort of FM patients and healthy controls in order to identify supraspinal structures that show graduated responses to increasing levels of painful pressure.

Methods: Pressure stimuli producing subjective levels of low, moderate and high pain were determined for 18 FM patients and 9 healthy controls. In subsequent 10min fMRI sessions, these pressures were applied in random order (25s stimulus duration, 50s interstimulus interval) to the left thumb nail bed. FMRI scans of the entire brain were obtained at 5s intervals. The data were intensity normalized, spatially smoothed and transformed into standard space.

Results: A comparison of the high pain stimulus and rest showed similar activations in both groups in contralateral primary and secondary somatosensory cortex, inferior parietal lobule, anterior insula, putamen and ipsilateral cerebellum. Correlating the three levels of painful stimuli with the fMRI signal showed similar associations in both groups in contralateral primary and secondary somatosensory cortex.

Conclusion: The results support our previous findings that similarly subjectively intense stimuli, produced by lower levels of stimulation in FM, result in comparable increases in the fMRI signal in clinical and control subjects. The correlation between stimulus intensity and cerebral response in the contralateral somatosensory regions indicates that the mechanisms responsible for pain amplification in FM preserve the pattern of stimulus intensity coding in the CNS observed in healthy controls.

Disclosure: This study was supported by Army grant 17-00-6042.




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health Pioneer Scientists Uncover a Revolutionary Neuroprotective Supplement for Nerve Health
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map