ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Relief for IBS, Colitis, Crohn’s And More

Can Magnesium Relieve Your Tinnitus?

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Restoring NAD+ could reduce DNA damage accumulation

Whole-body vibration may be as effective as regular exercise

 
Print Page
Email Article

Hidden Toxin Gene in Chlamydia Linked to Chronic Illnesses

  [ 18 votes ]   [ Discuss This Article ]
By National Institute of Allergy and Infectious Diseases • www.ProHealth.com • November 19, 2001




NIH NEWS RELEASE

After more than 50 years of searching, scientists have discovered a key gene that enables certain bacteria to cause blindness and debilitating genital tract infections.

Using the recently completed genetic blueprint of the bacterium "Chlamydia trachomatis", researchers from the National Institute of Allergy and Infectious Diseases (NIAID) have found a gene that encodes a cell-destroying toxin. Long suspected but never identified, the toxin helps explain why only some chlamydial strains cause chronic illness.

The discovery, described in the "Proceedings of the National Academy of Sciences" November 13, 2001 online early edition, opens potential new avenues for treating or preventing chlamydial diseases. It also highlights how DNA sequencing can help scientists identify new ways to combat disabling or deadly infections.

Unlike most bacteria, "C. trachomatis" lives inside cells. Chronic infections of the eyelids can scar the eyes and lead to trachoma, the most common cause of preventable blindness worldwide. In the United States, "C. trachomatis" infection is the most common sexually
transmitted disease (STD) and can lead to pelvic inflammatory disease, tubal pregnancies and infertility in women. All of these diseases are caused by chronic inflammation at the site of infection, but not all "C. trachomatis" strains produce this effect. Since the late 1940s, researchers have believed a toxin might cause the inflammation, but no such toxin had ever been found.

"These bacteria cause debilitating illnesses in hundreds of millions of people throughout the world," says Harlan Caldwell, Ph.D., a leading chlamydia researcher at NIAID's Rocky Mountain Laboratories in Hamilton, MT. "If we could find a toxin that helps the bacteria attack and destroy cells, we would have a major new target for diagnostic tests, vaccines and drugs."

Dr. Caldwell joined Robert Belland, Ph.D., and their colleagues to look for the toxin using a new tool: the genetic blueprint of "C. trachomatis". The researchers compared the genomes of two "C. trachomatis" strains: one that is restricted to mucosal surfaces and infects the eyes and genital tract, and one that is invasive and infects cells in the lymph nodes. The genes of the two strains were almost identical except for a single region of the bacterial chromosome. When the investigators studied that region in more detail, they found a stretch of DNA that resembled a known gene for the so-called toxin B of "Clostridium difficile". That bacterium causes a
potentially fatal infection of the large intestine in humans and is closely related to the deadly microbes that cause tetanus, botulism and gangrene. Toxin B makes the protein scaffolding inside of cells collapse, causing the cells that line mucosal passageways to separate from one another.

The "C. difficile" bacteria can then use the spaces between the cells to invade deeper into the intestinal wall.

To see if the candidate gene found in "C. trachomatis" actually encoded a protein similar to clostridial toxin B, Drs. Caldwell and Belland looked for evidence of the toxin in the bacteria. Their studies showed that "C. trachomatis" produces specific changes in infected cells,
and those changes are indistinguishable from ones induced by the clostridial toxin. Infected cells also contained toxin-encoding RNA, a type of DNA photocopy that shuttles its genetic instructions to the cell's protein-making machinery. The researchers also showed that infected cells contain a protein resembling toxin B, suggesting the cells deciphered the RNA's instructions.

"Finding the toxin would have been nearly impossible without the genome information," says Dr. Belland. Without it, he explains, the search would have resembled the proverbial needle in a haystack. The genome gave them a good idea of what haystack the needle was in, where it was
located, and what the needle might look like.

Anthony S. Fauci, M.D., director of NIAID, agrees that genome sequencing offers great promise in improving global health. "Determining the DNA sequence of the world's leading infectious microbes is a high priority within NIAID," he states. "This study is one example of how that commitment can provide researchers with a powerful tool for understanding and eventually treating or preventing
infectious diseases."

The discovery of a specific toxin associated with trachoma and STD-causing "C. trachomatis" strains is a boon to investigators trying to understand these diseases. Drs. Caldwell and Belland plan to continue their studies to determine how the toxin helps the bacteria cause disease and how it interacts with a person's immune system.

Further investigations should reveal new ways to attack the bacteria, perhaps by using an antitoxin vaccine, as is done with tetanus and diphtheria, or by developing drugs that block the toxin's ability to destroy cells.

NIAID is a component of the National Institutes of Health (NIH). NIAID supports basic and applied research to prevent, diagnose, and treat infectious and immune-mediated illnesses, including HIV/AIDS and other sexually transmitted diseases, tuberculosis, malaria, autoimmune disorders, asthma and allergies.

REFERENCE:
RJ Belland, et al. "Chlamydia trachomatis" cytotoxicity
associated with complete and partial toxin genes.
"Proceedings of the National Academy of Sciences" Early
Edition online (Nov. 13, 2001).



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Live Without Anxiety or Stress Live Without Anxiety or Stress
The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map