ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

On-and-off fasting helps fight obesity, study finds

Can Pomegranates Slow Aging?

Calorie restriction promotes longevity through effects on mitochondrial network

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

A spoonful of oil: Fats and oils help to unlock full nutritional benefits of veggies, study suggests

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

How Can You Benefit From Vitamin B12?

Drug can dramatically reduce weight of people with obesity

What Is Bitter Orange?

 
Print Page
Email Article

Chronic Fatigue Syndrome News: Scientists Find Hidden Piece of Influenza Virus

  [ 5 votes ]   [ Discuss This Article ]
By National Institute of Allergy and Infectious Diseases • www.ProHealth.com • December 3, 2001




For nearly 20 years, scientists have labored under the assumption that the influenza virus comprises only 10 protein molecules that form its structure and carry out its activities. However, this week in "Nature Medicine" researchers report finding a new, "hidden" influenza virus protein. This protein may kill immune system cells that fight the virus, thereby contributing to the virus's potency, the researchers say.

"We believe this is a groundbreaking finding, although we're not yet sure how deep the ground is," says Jonathan Yewdell, M.D., Ph.D., a viral immunologist who led a team of scientists at the National Institute of Allergy and Infectious Diseases (NIAID). "This might be the 'grand canyon' of the flu, in terms of understanding this virus's virulence, or perhaps only a narrow side ravine."

The scientists turned up this new protein by accident, while sifting through bits and pieces of "junk" peptides. Junk peptides are short protein molecules the virus creates once it infects a cell and begins replicating. They form when the process that translates viral genes into proteins goes awry, Dr. Yewdell explains. In other words, junk peptides result from genetic mistakes.

"We weren't looking for new proteins at all. We assumed the 10 known influenza proteins were all there were," Dr. Yewdell says. "We just wanted to know if immune system cells had learned to recognize any of these junk peptides. We thought that was an interesting question."

The immune system cells of mice, in fact, did recognize one of the peptides. When the scientists examined the gene encoding this peptide more closely, they noticed it was "suspiciously long" for mere junk. Wondering if this molecule might be a bona fide protein, Dr. Yewdell's team decided to see how much of it was created in cells infected with the flu virus. If it were junk, there should be only a few random copies of the peptide here and there. If it were a protein, large quantities of the molecule should be present. Dr. Yewdell used a technique called immunofluorescence, which makes the molecule glow green, to show how much of it infected cells contained.

"The cells we looked at just lit up," Dr. Yewdell says. "We saw large amounts of this molecule in the mitochondria of flu infected cells, and we knew it was a real protein. It was one of those 'eureka' moments of discovery you live for in science. The junk turned out to be a jewel."

It turns out that this protein is created when ribosomes, the cellular machines that translate genes into proteins, begin reading the influenza gene called PB-1 in what was previously believed to be the wrong location. "One could say that lurking within the PB-1 gene is an overlapping gene that codes for this protein," explains Dr. Yewdell. "This alternate translation may have started out as a mistake, but the protein it produced was useful, so through evolution the gene was maintained and improved."

Tests showed the protein is toxic to human cells, especially immune system cells. "Next, we plan to learn more about the functions of this protein and how it accomplishes its tasks," Dr. Yewdell says. The team also wants to know whether this protein might have contributed to the virulence of the flu viruses that caused the Asian flu of 1957, the Hong Kong flu of 1968, and especially the Spanish flu of 1918, which killed 20 million people worldwide.

"Like many scientific discoveries, this one happened serendipitously, and it confirms the importance of supporting basic research on infectious diseases," concludes Anthony S. Fauci, M.D., NIAID director. "When you have good researchers exploring interesting questions, they are bound to turn up crucial information."

NIAID is a component of the National Institutes of Health (NIH). NIAID supports basic and applied research to prevent, diagnose, and treat infectious and immune-mediated illnesses, including HIV/AIDS and other sexually transmitted diseases, tuberculosis, malaria, autoimmune disorders, asthma and allergies.

Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.

REFERENCE:
W. Chen, et al. A novel influenza A virus mitochondrial protein that induces cell death. "Nature Medicine" 17(12):1306-12 (2001)



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra EPA  - Fish Oil Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map