ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tea drinkers have lower glaucoma risk

Why Is Chlorella Considered a Superfood?

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Wonderful White Tea: A Drink Fit for an Emperor

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

 
Print Page
Email Article

FDA Approves Kineret for the Treatment of Rheumatoid Arthritis

  [ 63 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 28, 2001




The U.S. Food and Drug Administration has approved Kineret(TM) (anakinra) for the reduction of signs and symptoms of moderately to severely active rheumatoid arthritis (RA) in adult patients who have failed one or more disease modifying antirheumatic drugs (DMARDs).

Kineret, produced by Amgen, is the first direct and selective blocker of interleukin-1 (IL-1), a protein present in excess in RA patients. By blocking IL-1, Kineret inhibits the inflammatory response in RA including pain, and can be used alone or in combination with DMARDs, other than Tumor Necrosis Factor (TNF) blocking agents.

Approval of Kineret was based on a total of 2,932 patients studied in randomized, double-blinded, placebo-controlled clinical trials. Of the total patients, more than 2,600 were treated with Kineret. Kineret, taken alone or in combination with other commonly used disease-modifying therapies, improves the signs and symptoms of RA. Many clinical responses, including a decrease in inflammation and pain, were seen by the fourth week of treatment and most were seen by week 13.

After six months of therapy, 38 percent of Kineret patients, as compared with 22 percent of placebo patients, achieved a 20 percent improvement in the American College of Rheumatology (ACR) criteria. ACR20 criteria include a 20 percent improvement in the number of swollen and tender joints, plus a greater than or equal to 20 percent improvement in at least three of five of the following criteria: physician assessment of disease, patient assessment of disease, pain, C-reactive protein (a general laboratory marker of inflammation) and health assessment questionnaire.

"Kineret worked for many of my patients," said Dr. Stanley Cohen, clinical associate professor, University of Texas Southwestern Medical Center, and a clinical investigator in the Kineret trials. "I am impressed with the improvements in my patients' painful and swollen joints."

The most common side effect was a usually mild reaction at the site of injection, characterized by redness, swelling and pain. There was a risk of serious infections (2 percent in Kineret patients vs. less than 1 percent in placebo patients) in the clinical trials. Although Kineret should be discontinued if a patient develops an infection, most patients can continue taking Kineret after their infection resolves. Kineret should not be used with TNF blocking agents etanercept and infliximab. Preliminary data suggest a higher incidence of serious infection (7 percent) and the occurrence of neutropenia (3 percent) when Kineret is used with these agents.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Energy NADH™ 12.5mg Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
When a Negative is Positive - Goodnighties Recovery Sleepwear When a Negative is Positive - Goodnighties Recovery Sleepwear

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map