ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Ylang Ylang Oil Not Only Soothes Your Skin, but Your Mind as Well

Exercises to Help Prevent Urinary Incontinence

 
Print Page
Email Article

Abstract: Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [3H]imipramine reuptake in the primary fibromyalgia syndrome

  [ 30 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 20, 2002




Rheumatology 2001; 40: 290-296

Original Papers

E. Legangneux, J. J. Mora1, O. Spreux-Varoquaux2, I. Thorin, M. Herrou3, G. Alvado4 and C. Gomeni5. Department of Psychiatry, University of Caen,
1 Department of Rheumatology, Hospital of Bayeux,

2 Department of Pharmacology, Hospital of Versailles,

3 Department of Pharmacology, University of Caen,

4 Department of Surgery, Hospital of Bayeux and

5 Biotrial, rue Jean-Louis Bertrand, Rennes, France


Background. Primary fibromyalgia syndrome (PFS) is a chronic disorder commonly seen in rheumatological practice. The pathophysiological disturbances of this syndrome, which was defined by the American College of Rheumatology in 1990, are poorly understood. This study evaluated, in 30 patients, the hypothesis that PFS is a pain modulation disorder induced by deregulation of serotonin metabolism.

Objectives. To compare platelet [3H]imipramine binding sites and serotonin (5-HT) levels in plasma-rich platelets (PRP) of PFS patients with those of matched healthy controls and to compare the levels of biogenic amine metabolites in the cerebrospinal fluid (CSF) of PFS patients with those of matched controls.

Methods. Platelet [3H]imipramine binding sites were defined by two criteria, Bmax for their density and Kd for their affinity. PRP 5-HT and CSF metabolites of 5-HT (5-hydroxyindoleacetic acid, 5-HIAA), norepinephrine (3-methoxy, 4-hydroxy phenylglycol, MHPG) and dopamine (homovanillic acid, HVA) were assayed by reversed-phase high-performance liquid chromatography with coulometric detection.

Results. [3H]Imipramine platelet binding was similar (P=0.43 for Bmax and P=0.30 for Kd) in PFS patients (Bmax=901±83 fmol/mg protein, Kd=0.682±0.046) and in matched controls (Bmax=1017±119 fmol/mg protein, Kd=0.606±0.056). PRP 5-HT was significantly higher (P=0.0009) in PFS patients (955±101 ng/109 platelets) than in controls (633±50 ng/109 platelets).

When adjusted for age, the levels of all CSF metabolites were lower in PFS patients. The CSF metabolite of norepinephrine (MHPG) was lower (P=0.003) in PFS patients (8.33±0.33 ng/ml) than in matched controls (9.89±0.31 ng/ml) and 5-HIAA was lower (P=0.042) in PFS female patients (22.34±1.78 ng/ml) than in matched controls (25.75±1.75 ng/ml). For HVA in females, the difference between PFS patients (36.32±3.20 ng/ml) and matched controls (38.32±2.90 ng/ml) approached statistical significance (P=0.054).

Conclusion. Changes in metabolites of CSF biogenic amines appear to be partially correlated to age but remained diagnosis-dependent. High levels of PRP 5-HT in PFS patients were associated with low CSF 5-HIAA levels in female patients but were not accompanied by any change in serotonergic uptake as assessed by platelet [3H]imipramine binding sites. These findings do not allow us to confirm that serotonin metabolism is deregulated in PFS patients.


KEY WORDS: Primary fibromyalgia syndrome, Matched controls, Serotonin, Norepinephrine, Dopamine, Cerebrospinal fluid.

Correspondence to: E. Legangneux, Sanofi Synthelabo, 1 Av. Pierre Brossolette, F-91380 Chilly-Mazarin, France.

© 2001 British Society for Rheumatology




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Vitamin D3 Extreme™ Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map