ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

AMA journal associates iron deficiency with hearing loss

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Lutein linked to preservation of crystallized intelligence

 
Print Page
Email Article

MGN-3, A Novel Antitumor Agent?

  [ 89 votes ]   [ Discuss This Article ]
www.ProHealth.com • March 21, 2002




Uyemura, Koichi; Tarchiki, Ken; Ghoneurn, Mamdooh; Makinodan, Takashi; Makhijani Nalini; Yamaguchi, Dean UCLA Medical School/Greater Los Angeles VA Healthcare System, Los Angeles CA; Drew University of Medicine and Science, Los Angeles CA and UCLA School of Medicine/Greater Los Angeles VA Healthcare System, Los Angeles CA

There is great interest among health care professionals to explore the value of naturally derived biological response modifiers to enhance immune function. MGN-3 is a biological response modifier that is an arabinoxylan compound which is a polysaccharide containing hemicellulose-b extract of rice bran, modified by enzymes from Shiitake mushrooms reported previously to be a potent immunomodulator.

We have previously shown that treatment with MGN-3 had an augmentory effect on natural killer [NK] cell activity in healthy control subjects, in patients with breast cancer, and in patients infected with HIV-1. In these studies, an effect on NK cell activity was noted as early as 4 weeks and did not show hyporesponsiveness with continued treatment for over 12 months, with absence of notable side effects.

In the present study, we demonstrate a direct effect of MGN-3 on tumor cell growth and cytokine production. Preliminary results showed that incubation of a breast cancer cell line (MCF-7) with MGN-3 arrested tumor cell growth, whereas control MCF-12A cells grown in a media in the absence of added MGN-3 continued to increase in cell number.

Employing flow cytometry procedures, results showed that after 16 hours of treatment of MCF-7 cells with MGN-3 a marked stimulation in production of interleukin 10 {IL- 10}. ELISA analyses of the culture media bathing the cells 16 hours after treatment with MGN-3 also showed an increase in IL-10 production, little change in INF-g concentration. However, a marked elevation in Interlukin-12 was also observed at 16 hours.

In conclusion, our findings indicate that MGN-3 acts by not only enhancing the activity of NK cells as previously reported, but also through a direct action on tumor cell production of cytokines. The production of cytokines such as IL- 10 by cancer cells to alter the activity of the immune system is well known. Our findings indicate that the biological response modifier MGN-3 can alter the production and secretion of cytokines such as IL 10 and IL- 12 by cancer cells such as MCF-7; and thereby the activity of the immune system.

Findings that treatment of cultures of MCF-7 cells with MGN-3 also can arrest cell growth directly may reflect an alternate mechanism of control of tumor cell growth.

MGN-3, commercially known as Biobran, was provided by Daiwa Pharmaceuticals Company, Ltd. Tokyo, Japan. Work in this direction is in progress. Supported in part by VA Medical Research Funds and by funds provided by Daiwa Pharmaceuticals Company, Ltd, Tokyo, Japan.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Breaking Through the Mental Fog Breaking Through the Mental Fog
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Natural Bladder Control, Go Less and Live More Natural Bladder Control, Go Less and Live More

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map