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Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis

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By Author: RUSSELL-I-J; VAEROY-H; JAVORS-M; NYBERG-F • www.ProHealth.com • January 1, 1999


Objective: To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.

Methods: Metabolities of serotonin, norepinephrine, and dopamine were identified in CSF, using high performance liquid chromatography with coulometric detection.

Results: CSF levels of metabolites from all 3 neurotransmitters were lower in PFS patients than in controls.

Conclusion: A low rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.




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