ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Trial Finds Reduction in Depressive Symptoms Following Magnesium Supplementation

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

Carnitine deficiency suggested as contributor to autism

Vitamin D supplement use associated with lower risk of breast cancer

Hop Oil: A Safe Sleep Aide

White Camphor Oil: The Purest Camphor Oil

Lutein — An Important Nutrient for Eye and Brain Health

 
Print Page
Email Article

NSAIDs Triple Risk of Severe Upper Gastrointestinal Events

  [ 22 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 2, 2002





NEW YORK (Reuters Health) Apr 29 - The results of a meta-analysis of cohort and case control studies of severe upper gastrointestinal (GI) complications suggest that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of perforation, ulcers, and bleeds by a factor of approximately three, US investigators report.

Previously reported meta-analyses were marred by restrictions on type of study and language of publication, and by omission of nonpublished data, Dr. Joshua J. Ofman, of Cedars-Sinai Health System and Zynx Health Inc., in Beverly Hills, California, and associates note. Their analysis, which appears in The Journal of Rheumatology for April, attempts to overcome these restrictions.

The researchers evaluated 4881 published titles and identified randomized controlled trials involving three US Food and Drug Administration studies and 13 published reports regarding outcomes of perforation, ulcers and bleeds. They also evaluated 23 case control studies and 9 cohort studies.

Randomized control trials involved 4431 patients and yielded a pooled odds ratio of 5.36 compared with placebo. Case control studies, which contributed more than 25,000 patients, yielded a pooled odds ratio of 3.0.

When Dr. Ofman's group stratified their analysis according to whether studies were published before or after 1990, they found no significant difference between the results of randomized control trials and case control studies. However, the risk ratio for cohort studies that appeared before 1990 was 2.0, while the risk ratio for those published in 1990 or later was 3.4.

Dr. Ofman and his associates did not address differences between selective and nonselective cyclooxygenase (COX) inhibitors. In an editorial, Dr. Chris J. Hawkey, of the University Hospital Nottingham in the UK, recommends that similar analysis be conducted for both classes of drugs and for non-GI toxicities.

"The challenge of such studies will be to assess the effect of drugs on overall health, morbidity, and mortality," Dr. Hawkey concludes.

J Rheumatol 2002;29:804-812.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor® Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Live Without Anxiety or Stress Live Without Anxiety or Stress
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map