ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Tea drinkers have lower glaucoma risk

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Wonderful White Tea: A Drink Fit for an Emperor

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Try Apple Cider Vinegar and Black Cumin Oil as Your Go-To Salad Dressing

Chlorophyll: How to Get This Valuable Nutrient From Your Diet

 
Print Page
Email Article

NSAIDs Triple Risk of Severe Upper Gastrointestinal Events

  [ 22 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 2, 2002





NEW YORK (Reuters Health) Apr 29 - The results of a meta-analysis of cohort and case control studies of severe upper gastrointestinal (GI) complications suggest that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of perforation, ulcers, and bleeds by a factor of approximately three, US investigators report.

Previously reported meta-analyses were marred by restrictions on type of study and language of publication, and by omission of nonpublished data, Dr. Joshua J. Ofman, of Cedars-Sinai Health System and Zynx Health Inc., in Beverly Hills, California, and associates note. Their analysis, which appears in The Journal of Rheumatology for April, attempts to overcome these restrictions.

The researchers evaluated 4881 published titles and identified randomized controlled trials involving three US Food and Drug Administration studies and 13 published reports regarding outcomes of perforation, ulcers and bleeds. They also evaluated 23 case control studies and 9 cohort studies.

Randomized control trials involved 4431 patients and yielded a pooled odds ratio of 5.36 compared with placebo. Case control studies, which contributed more than 25,000 patients, yielded a pooled odds ratio of 3.0.

When Dr. Ofman's group stratified their analysis according to whether studies were published before or after 1990, they found no significant difference between the results of randomized control trials and case control studies. However, the risk ratio for cohort studies that appeared before 1990 was 2.0, while the risk ratio for those published in 1990 or later was 3.4.

Dr. Ofman and his associates did not address differences between selective and nonselective cyclooxygenase (COX) inhibitors. In an editorial, Dr. Chris J. Hawkey, of the University Hospital Nottingham in the UK, recommends that similar analysis be conducted for both classes of drugs and for non-GI toxicities.

"The challenge of such studies will be to assess the effect of drugs on overall health, morbidity, and mortality," Dr. Hawkey concludes.

J Rheumatol 2002;29:804-812.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
Supercharge Your Brain with Two Powerful Nutrients Supercharge Your Brain with Two Powerful Nutrients
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map