ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Basic Aromatherapy to Help Balance and Calm

Tea drinkers have lower glaucoma risk

Soy, cruciferous vegetables could help lower breast cancer treatment side effects

The Long-Term Benefits of Drinking Oolong Tea

Why You Should Try This Sweet-Smelling and Health-Boosting Essential Oil

Wonderful White Tea: A Drink Fit for an Emperor

Chamomile Tea: Why This Ancient Therapeutic Drink Still Stands Out Today

Arnica: This Powerful Herb Promotes Various Kinds of Healing

Get ‘Hooked’ on Cat’s Claw: The Many Benefits of This Amazonian Herb

Acid Reflux May Respond Better to Foods Than Prescribed Pills

 
Print Page
Email Article

New Treatment for Difficult-to-Treat Inflammatory Disease

  [ 21 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 3, 2002





Hypereosinophilic syndrome (HES) is an occasional disorder
in which eosinophils, a type of inflammation-causing white blood cell, increase to excessive levels in the blood. The cells accumulate throughout the body and unleash powerful chemicals that can damage many different organs, including the heart, nervous system, skin, kidneys and digestive tract. Grantees of the National Institute of Allergy and Infectious Diseases (NIAID) have now used an existing cancer drug to effectively treat the disease in many individuals.

Eosinophils are a key component of anti-parasite immune responses and also play a central role in allergies. During HES, however, the cells appear in large numbers even though an underlying cause for their production is not known. The disease mostly affects men. Steroids, hydroxyurea and alpha interferon have all been used to treat the disease, but often unsuccessfully. Even when those treatments do work, they often cause unwanted side effects.

In a letter appearing in this week's "The Lancet", Gerald Gleich, M.D., and colleagues from the Mayo Clinic and Foundation in Rochester, Minn., describe how a drug used to treat a form of leukemia is remarkably successful at reducing eosinophil levels in people with HES. The drug, imatinib mesylate, reduced eosinophil levels to normal in four of five patients studied and completely eliminated their symptoms.

"It's a different world," says Dr. Gleich, who has since
moved to the University of Utah. "The disease is gone as
long as the patients continue to take their medication."

The only patient who did not respond to the drug had
elevated levels of interleukin-5, or IL-5, a protein in the blood that helps promote the growth of eosinophils. It is therefore likely that the drug was unable to work because IL-5 was constantly triggering the cells to reproduce.

Imatinib mesylate inhibits several enzymes that help
regulate a cell's growth and reproduction. Its ability to
shut down certain cancerous cells explains its
effectiveness against leukemia. The HES patients received
a much lower dose than is used in cancer treatment,
however, suggesting eosinophils may contain a similar
enzyme that is much more sensitive to the drug.

The low dosage also means people with HES may be able to
keep their disease under control with a simple, inexpensive regimen. "The disease may be kept under control with two pills a week, compared to the four pills a day used to treat myelogenous leukemia," explains Dr. Gleich.

The study, though small, offers promise to people affected
by HES. By highlighting how IL-5 and a potentially unknown enzyme might regulate eosinophils, the study also hints at new avenues for research. Says Dr. Gleich, "There is a crying need for a larger study."

NIAID is a component of the National Institutes of Health (NIH). NIAID supports basic and applied research to prevent, diagnose, and treat infectious and immune-mediated illnesses, including HIV/AIDS and other sexually transmitted diseases, illness from potential agents of bioterrorism, tuberculosis, malaria, autoimmune disorders, asthma and allergies.

Press releases, fact sheets and other NIAID-related
materials are available on the NIAID Web site at http://www.niaid.nih.gov.

The National Institute of Allergy and Infectious Diseases
is a component of the National Institutes of Health,
U.S. Department of Health and Human Services.

REFERENCE:

GJ Gleich et al. Treatment of the hypereosinophilic
syndrome with imatinib mesylate. "The Lancet" 359:1577-8 (2002).



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Vitamin D3 Extreme™ Ultra EPA  - Fish Oil


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map