Abstract: Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions
May 13, 2002
Journal: Ann N Y Acad Sci 2001 Mar;933:201-10
Authors: Mullington JM, Hinze-Selch D, Pollmacher T.
Affiliation: Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. mailto:firstname.lastname@example.org
NLM Citation: PMID: 12000021
In humans, activation of the primary host defense system leads to increased or decreased NREM sleep quality, depending on the degree of early immune activation.
Modest elevations of certain inflammatory cytokines are found during experimental sleep loss in humans and, in addition, relatively small elevations of cytokines are seen following commencement of pharmacological treatments with clozapine, a CNS active antipsychotic agent, known to have immunomodulatory properties.
Cytokines such as TNF-alpha, its soluble receptors, and IL-6, present in the periphery and the CNS, comprise a link between peripheral immune stimulation and CNS-mediated behaviors and experiences such as sleep, sleepiness, and fatigue.
The debilitating fatigue experienced in chronic fatigue syndrome and related diseases may also be related to altered cytokine profiles.