ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Women With Fibromyalgia Have Impaired Growth Hormone Secretion

  [ 235 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 5, 2002




A DGReview of:"Impaired growth hormone secretion in fibromyalgia patients: Evidence for augmented hypothalamic somatostatin tone"

Source: Arthritis & Rheumatism Volume 46, Issue 5, 2002

By Anne MacLennan

Women with fibromyalgia have an impaired growth hormone response to exercise that is reversible with pyridostigmine.

This impaired response exists even in fibromyalgia (FM) patients with normal levels of insulin-like growth factor-one (IGF-one), Eduardo S. Paiva and colleagues from Oregon Health Sciences University, Portland, Oregon, United States, have found.

Because pyridostigmine reduces somatostatin tone, this defective growth hormone (GH) response may result from higher levels of somatostatin, a hypothalamic hormone that inhibits GH secretion, these authors surmise.

The two-fold objective of this study was to determine the GH response to acute exercise stressor in female FM patients and to assess the importance of somatostatin tone in the generation of this response.

Twenty women with FM and 10 healthy female controls, all of whom exercised on a treadmill to their own idea of exhaustion, were monitored for pulse, blood pressure, electrocardiography, oxygen uptake, carbon dioxide output, anaerobic threshold and maximal workload. Researchers drew blood for GH and cortisol measures one hour before exercise, and then again immediately before, immediately after and one hour after exercise.

This entire procedure was precisely repeated one month later, except now all of the women received pyridostigmine bromide (Mestinon; 30 mg orally) one hour before exercise.

Although FM patients versus controls showed no GH or cortisol response to exercise, their GH levels increased eight-fold after receiving the pyridostigmine to a value comparable with that of controls.

In the FM patients, pyridostigmine did not increase the cortisol response to exercise and did not alone stimulate GH secretion, nor did it improve exercise-induced GH secretion in controls.

FM patients with normal IGF-one levels were also found to have an impaired GH response to exercise.

Arthritis & Rheumatism Volume 46, Issue 5, 2002. Pages: 1344-1350.

STUDY ABSTRACT:

Impaired growth hormone secretion in fibromyalgia patients: Evidence for augmented hypothalamic somatostatin tone

Eduardo S. Paiva, Atul Deodhar, Kim D. Jones, Robert Bennett *
Oregon Health Sciences University, Portland
*Correspondence to Robert Bennett, Department of Medicine (OP09), Oregon Health Sciences University, Portland, OR 97201

Funded by:
USPHS; Grant Number: 5-M01-RR-00334

Objective: To determine whether female fibromyalgia (FM) patients exhibit a normal growth hormone (GH) response to an acute exercise stressor, and to assess the importance of somatostatin tone in the generation of this GH response.

Methods: Twenty female FM patients were compared with 10 healthy female controls. All subjects exercised to volitional exhaustion on a treadmill. A standard metabolic cart was used to monitor pulse, blood pressure, electrocardiography, oxygen uptake, carbon dioxide output, anaerobic threshold, and maximal workload. Blood was drawn for GH and cortisol measurements 1 hour before exercise, immediately before exercise, immediately after exercise, and 1 hour after exercise. One month later, testing that was exactly similar was performed, except all subjects were given pyridostigmine bromide (Mestinon; 30 mg orally) 1 hour before exercise.

Results: Compared with controls, FM patients failed to exhibit a GH or cortisol response to acute exercise (P = 0.003). After administration of pyridostigmine, 1 hour before exercise, the GH levels of FM patients increased 8-fold (P = 0.001), to a value comparable with that of controls.

Pyridostigmine did not increase the cortisol response to exercise in FM patients. Pyridostigmine alone did not stimulate GH secretion in FM patients, nor did it improve exercise-induced GH secretion in controls. FM patients with normal insulin-like growth factor 1 (IGF-1) levels had an impaired GH response to exercise.

Conclusion: Three new findings are reported: 1) FM patients have a reduced GH response to exercise, 2) pyridostigmine reverses this impaired response, and 3) defective GH secretion in FM can occur in patients with normal IGF-1 levels. Because pyridostigmine is known to reduce somatostatin tone, it is surmised that the defective GH response to exercise in FM patients probably results from increased levels of somatostatin, a hypothalamic hormone that inhibits GH secretion.

Received: 5 June 2001; Accepted: 5 December 2001



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra EPA  - Fish Oil Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3 Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant Improvements in Memory, Learning, and Cognition.3
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map