ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How Can You Benefit From Vitamin B12?

Discover Why Ashwagandha Can Be Used for Stress and Anxiety

Calorie restriction promotes longevity through effects on mitochondrial network

Lower magnesium levels linked with increased mortality risk during up to 40 years of follow-up

Higher resveratrol dose linked to lower glucose levels in type 2 diabetics

Tryptophan's Possible Effects for Your Health

What Is Bitter Orange?

Black Tea Is Great for Your Gut

Drug can dramatically reduce weight of people with obesity

Ashwagandha Helps Hormones - Aids Arthritis

 
Print Page
Email Article

Monitoring a Hypothetical Channelopathy in Chronic Fatigue Syndrome

  [ 24 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 20, 2002


J Nijs,[1,6] PT; C Demanet, [5] MD, PhD; N McGregor, [3] MDSc, PhD; P De Becker, [1] PhD; M Verhas, [4] MD, PhD; P Englebienne, [4] PhD; and K De Meirleir, [1,2] MD, PhD

1: Department of Human Physiology, Faculty of Physical Education and Physical Therapy, Vrije Universiteit Brussel,Belgium

2: Fatigue Clinic, Vrije Universiteit Brussel, Belgium

3: Collaborative Pain Research Unit, Department of Biological Sciences, Faculty of Science, University of Newcastle,, Callaghan, New South Wales, Australia

4: Department of Nuclear Medicine, Brugmann Hospital / Academic Hospital, Vrije Universiteit Brussel and UniversitŽ Libre Bruxelles (V.U.B Ð U.L.B.), Brussels, Belgium

5: Division of Hematology and Immunology, Academic Hospital Vrije Universiteit, Brussel, Belgium

6: To whom correspondence should be addressed: Vakgroep MFYS, AZ-VUB KRO gebouw, 1, Laarbeeklaan 101, 1090, Brussel, Belgium
Tel: +32 2 477 4604. Fax: +32 2 477 4607. E-mail: Jo.Nijs@vub.ac.be

This study aimed at monitoring of a previously suggested channelopathy in Chronic Fatigue Syndrome, and at searching for possible explanations by means of immune system characteristics.

Twenty-seven CFS patients and 20 age and sex matched healthy volunteers were recruited. RNase L-ratio, % of the norm of whole body potassium content, serum electrolytes (sodium, calcium and potassium), immune cells, blood cell count and erythrocyte sedimentation rate were determined.

More than fifty percent of our patients presented with abnormal whole body potassium content. Eight patients had increased, while six had depleted potassium content. Discriminant function analysis revealed that the CFS patients and control subjects could be differentiated on immunophenotyping with the predominant cell differences being the increase in CD19+CD5+ (mature B-) cells and the decrease in CD3-CD16+CD56+ (NK) cells in both the percentage and count distributions. The fall in NK-cells was very strongly associated with increases in the RNase L-ratio and falls in serum calcium levels. In addition, four patients with low serum calcium levels showed lower whole body potassium levels.

In conclusion, these observations provide evidence for a channelopathy in an important subset of CFS-patients, probably induced by the deregulated 2,5A RNase L antiviral pathway. Proteolytic cleavage of 80 kDa RNase L generates ankyrin repeat motif-containing fragments. RLI (RNase L inhibitor) takes part of the ATP binding cassette (ABC) superfamily, and is capable of binding ankyrin-like fragments in CFS-patients. Consequently, ankyrin fragments, released by RNase L cleavage, interacts with the ABC-ankyrin domain interaction and deregulation of proper ABC transporters function is inevitable.

Source: www.ahmf.org. Presented at the 2001 Clinical and Scientific Meeting: Myalgic Encephalopathy/Chronic Fatigue Syndrome: "The Medical Practitioners' Challenge in 2001."



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Herbal Rescue for High Blood Sugar Herbal Rescue for High Blood Sugar

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map