ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

Meet Your Weight Loss Goals

AMA journal associates iron deficiency with hearing loss

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on DNA

 
Print Page
Email Article

Are cortisol levels low in Chronic Fatigue Syndrome?: A Meta-Analysis

  [ 28 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 20, 2002


A. Harvey, G. Purdie, J. Bushnell, P. Ellis

Department of Psychological Medicine,  Wellington School of Medicine and Health Sciences,  University of Otago, NZ

A number of studies suggest that cortisol may be lower in Chronic Fatigue Syndrome (CFS) than in healthy controls, whereas other studies have reported less convincing results.

Objective: To conduct a meta-analysis aimed at determining the status of hypocortisolism in CFS.

Methods:  Literature searches were carried out using Medline, PsycLIT, EMBASE, PsycINFO and relevant articles in peer reviewed journals. Inclusion criteria were; application of either the CDC (1988, 1994) or the Oxford (1991) diagnostic criteria, and comparable healthy controls. To investigate sources of heterogeneity, the test statistic Q was applied to the data. 24-hr UFC cortisol measures were compared with am and pm plasma cortisol samples and clinical variability was examined by performing a separate analysis on studies that had recruited patients through tertiary care providers as opposed to primary care.

Results:  14 published studies (k) were found that met the inclusion criteria; n=344 CFS patients and n=272 healthy controls. A significant (p<0.0001) low to moderate effect size was found (-0.36) for reduced basal cortisol levels in CFS. However, there was significant heterogeneity amongst the studies (p<0.0001). Investigation of methodological differences revealed that 24-hr urinary cortisol were better at measuring basal cortisol levels, increasing the effect size (EF = -0.73, k=4), although there was still significant heterogeneity (p<0.01). Morning plasma cortisol levels also showed a significant effect size (EF = -0.35, k=4), substantially reducing the heterogeneity (p=0.50). Afternoon and evening plasma samples were unable to distinguish between groups (EF = 0.01, k=7), the heterogeneity was also reduced (p=0.045). Analysis of 7 studies that reported recruiting patients from tertiary care increased the effect size (EF = Ð0.63), although there was significant heterogeneity (p<0.01).

Conclusion:  Reduced basal cortisol levels are relevant to the experience of Chronic Fatigue Syndrome. Patients seen in tertiary care perhaps show more endocrine abnormalities and clinical methodologies seem to be important in assessment procedures.

Source: www.ahmf.org. Presented at the 2001 Clinical and Scientific Meeting: Myalgic Encephalopathy/Chronic Fatigue Syndrome: "The Medical Practitioners' Challenge in 2001.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Safely Burn Away Body Fat Safely Burn Away Body Fat
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map