ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Are cortisol levels low in Chronic Fatigue Syndrome?: A Meta-Analysis

  [ 28 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 20, 2002


A. Harvey, G. Purdie, J. Bushnell, P. Ellis

Department of Psychological Medicine,  Wellington School of Medicine and Health Sciences,  University of Otago, NZ

A number of studies suggest that cortisol may be lower in Chronic Fatigue Syndrome (CFS) than in healthy controls, whereas other studies have reported less convincing results.

Objective: To conduct a meta-analysis aimed at determining the status of hypocortisolism in CFS.

Methods:  Literature searches were carried out using Medline, PsycLIT, EMBASE, PsycINFO and relevant articles in peer reviewed journals. Inclusion criteria were; application of either the CDC (1988, 1994) or the Oxford (1991) diagnostic criteria, and comparable healthy controls. To investigate sources of heterogeneity, the test statistic Q was applied to the data. 24-hr UFC cortisol measures were compared with am and pm plasma cortisol samples and clinical variability was examined by performing a separate analysis on studies that had recruited patients through tertiary care providers as opposed to primary care.

Results:  14 published studies (k) were found that met the inclusion criteria; n=344 CFS patients and n=272 healthy controls. A significant (p<0.0001) low to moderate effect size was found (-0.36) for reduced basal cortisol levels in CFS. However, there was significant heterogeneity amongst the studies (p<0.0001). Investigation of methodological differences revealed that 24-hr urinary cortisol were better at measuring basal cortisol levels, increasing the effect size (EF = -0.73, k=4), although there was still significant heterogeneity (p<0.01). Morning plasma cortisol levels also showed a significant effect size (EF = -0.35, k=4), substantially reducing the heterogeneity (p=0.50). Afternoon and evening plasma samples were unable to distinguish between groups (EF = 0.01, k=7), the heterogeneity was also reduced (p=0.045). Analysis of 7 studies that reported recruiting patients from tertiary care increased the effect size (EF = Ð0.63), although there was significant heterogeneity (p<0.01).

Conclusion:  Reduced basal cortisol levels are relevant to the experience of Chronic Fatigue Syndrome. Patients seen in tertiary care perhaps show more endocrine abnormalities and clinical methodologies seem to be important in assessment procedures.

Source: www.ahmf.org. Presented at the 2001 Clinical and Scientific Meeting: Myalgic Encephalopathy/Chronic Fatigue Syndrome: "The Medical Practitioners' Challenge in 2001.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map