ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is a Good Night's Sleep at the Top of Your Wishlist?

Ashwagandha Helps Hormones - Aids Arthritis

Why You Should Be Eating More Porcini Mushrooms

A Breathalyzer for Disease?

Tryptophan's Possible Effects for Your Health

How Bacopa Can Help Improve Your Cognitive Function

Black Tea Is Great for Your Gut

Magnesium Reduces Diabetes and Helps Keep You Young

Lavender Aromatherapy Can Ease Pre-Op Anxiety

Mint: Learn More About This Refreshing and Invigorating Herb

 
Print Page
Email Article

Are cortisol levels low in Chronic Fatigue Syndrome?: A Meta-Analysis

  [ 28 votes ]   [ Discuss This Article ]
www.ProHealth.com • June 20, 2002


A. Harvey, G. Purdie, J. Bushnell, P. Ellis

Department of Psychological Medicine,  Wellington School of Medicine and Health Sciences,  University of Otago, NZ

A number of studies suggest that cortisol may be lower in Chronic Fatigue Syndrome (CFS) than in healthy controls, whereas other studies have reported less convincing results.

Objective: To conduct a meta-analysis aimed at determining the status of hypocortisolism in CFS.

Methods:  Literature searches were carried out using Medline, PsycLIT, EMBASE, PsycINFO and relevant articles in peer reviewed journals. Inclusion criteria were; application of either the CDC (1988, 1994) or the Oxford (1991) diagnostic criteria, and comparable healthy controls. To investigate sources of heterogeneity, the test statistic Q was applied to the data. 24-hr UFC cortisol measures were compared with am and pm plasma cortisol samples and clinical variability was examined by performing a separate analysis on studies that had recruited patients through tertiary care providers as opposed to primary care.

Results:  14 published studies (k) were found that met the inclusion criteria; n=344 CFS patients and n=272 healthy controls. A significant (p<0.0001) low to moderate effect size was found (-0.36) for reduced basal cortisol levels in CFS. However, there was significant heterogeneity amongst the studies (p<0.0001). Investigation of methodological differences revealed that 24-hr urinary cortisol were better at measuring basal cortisol levels, increasing the effect size (EF = -0.73, k=4), although there was still significant heterogeneity (p<0.01). Morning plasma cortisol levels also showed a significant effect size (EF = -0.35, k=4), substantially reducing the heterogeneity (p=0.50). Afternoon and evening plasma samples were unable to distinguish between groups (EF = 0.01, k=7), the heterogeneity was also reduced (p=0.045). Analysis of 7 studies that reported recruiting patients from tertiary care increased the effect size (EF = Ð0.63), although there was significant heterogeneity (p<0.01).

Conclusion:  Reduced basal cortisol levels are relevant to the experience of Chronic Fatigue Syndrome. Patients seen in tertiary care perhaps show more endocrine abnormalities and clinical methodologies seem to be important in assessment procedures.

Source: www.ahmf.org. Presented at the 2001 Clinical and Scientific Meeting: Myalgic Encephalopathy/Chronic Fatigue Syndrome: "The Medical Practitioners' Challenge in 2001.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Vitamin D3 Extreme™ FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Supercharge Your Brain with Two Powerful Nutrients Supercharge Your Brain with Two Powerful Nutrients
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Enhance Eyelashes Naturally Enhance Eyelashes Naturally

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map