ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Prevent Or Reverse Diabetes: An Amazing Herbal Intervention

Exercise and Vitamin D Better Together for Heart Health

VIDEO: Essential Oils for Weight Loss

Can Ginkgo Give Your Brain a Boost?

Can Valerian Root Help You Sleep Better?

Fighting Statin-Induced Diabetes with CoQ10

Eight servings of veggies a day is clearly best for the heart

The Many Wonders of Calming Sandalwood Oil

Curcumin — A Novel Treatment Alternative for Depression

How Glycation Accelerates Aging

 
Print Page
Email Article

Structure of Lyme Disease Borellia Surface Protein Defines Variable Antigenic Area

  [ 38 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 2, 2002


NEW YORK (Reuters Health) Jun 25 - Investigators in Texas have determined the structure of the highly variable region of an outer lipoprotein of Borrelia burgdorferi that enables the spirochete to evade a mammalian host's immune response.

The lipoprotein, VlsE, is encoded by the variable major protein (VMP)-like sequence (vls) locus, Dr. James C. Sacchettini and associates report in the June 14th issue of the Journal of Biological Chemistry.

It is believed that VlsE plays an important role in mammalian infection because loss of the plasmid that encodes this protein results in reduced infectivity of the bacterium, the researchers explain. While VlsE induces a strong antibody response in infected mammals, rapid antigenic variation is believed to promote immune evasion.

Previous research in mice has shown that sequence changes are present within 4 days of infection, and by 28 days "every isolate from skin or other tissues is unique and contains roughly 9 to 13 recombination events," Dr. Sacchettini's team points out.

To investigate "the relationship between VlsE structure and antigenicity," Dr. Sacchettini, of Texas A&M University in College Station, and his colleagues examined the VlsE1 variant of B. burgdorferi by X-ray crystallography to elucidate its three-dimensional structure.

They found that six variable regions of VlsE form loop structures around predominantly invariant portions of the protein. "The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion," they report.

In a university statement, Dr. Sacchettini stated, "these structures provide a roadmap to the development of new diagnostics as well as effective vaccines."

J Biol Chem 2002;277:21691-21696.



Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Energy NADH™ 12.5mg Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map