ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Fighting Heartburn and Gerd Naturally – And Safely!

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Structure of Lyme Disease Borellia Surface Protein Defines Variable Antigenic Area

  [ 38 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 2, 2002


NEW YORK (Reuters Health) Jun 25 - Investigators in Texas have determined the structure of the highly variable region of an outer lipoprotein of Borrelia burgdorferi that enables the spirochete to evade a mammalian host's immune response.

The lipoprotein, VlsE, is encoded by the variable major protein (VMP)-like sequence (vls) locus, Dr. James C. Sacchettini and associates report in the June 14th issue of the Journal of Biological Chemistry.

It is believed that VlsE plays an important role in mammalian infection because loss of the plasmid that encodes this protein results in reduced infectivity of the bacterium, the researchers explain. While VlsE induces a strong antibody response in infected mammals, rapid antigenic variation is believed to promote immune evasion.

Previous research in mice has shown that sequence changes are present within 4 days of infection, and by 28 days "every isolate from skin or other tissues is unique and contains roughly 9 to 13 recombination events," Dr. Sacchettini's team points out.

To investigate "the relationship between VlsE structure and antigenicity," Dr. Sacchettini, of Texas A&M University in College Station, and his colleagues examined the VlsE1 variant of B. burgdorferi by X-ray crystallography to elucidate its three-dimensional structure.

They found that six variable regions of VlsE form loop structures around predominantly invariant portions of the protein. "The surface localization of the variable amino acid segments appears to protect the conserved regions from interaction with antibodies and hence may contribute to immune evasion," they report.

In a university statement, Dr. Sacchettini stated, "these structures provide a roadmap to the development of new diagnostics as well as effective vaccines."

J Biol Chem 2002;277:21691-21696.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Energy NADH™ 12.5mg Ultra ATP+, Double Strength


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map