ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Restoring NAD+ could reduce DNA damage accumulation

 
Print Page
Email Article

Researchers Identify Key Protein That Establishes Communication Within Central Nervous System

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 4, 2002


DALLAS – Aug. 30, 2002 – Researchers at UT Southwestern Medical Center at Dallas have identified one of the key proteins involved in the establishment of the central nervous system.

The researchers found that the protein, SynCAM, plays a major role in the formation of synapses, which are specialized junctions at which a neuron communicates with a target nerve cell. Neurons receive and send electrical signals over long distances within the body. The process of synaptic transmission drives communication between neurons in the brain and underlies all brain function.

This is only the second study that cites the initial events leading to the formation of synapses in the central nervous system, said Dr. Thomas Biederer, a postdoctoral researcher in the Center for Basic Neuroscience and lead author of the study, reported in the Aug. 30 issue of Science.

“Until this discovery very little was known about how neurons form synapses with each other,” Biederer said. “We defined how the initial contact points are being developed and from there we can figure out how the young nervous system grows into an active network.”

Synaptic formation is important in both newborns and adults. In newborns, synapses are formed rapidly and abundantly. The central nervous system, which encompasses the brain and spinal cord, establishes a stable network by keeping those that are functionally important and eliminating those that are not important. In adults, there is constant remodeling of neurons and synapses that relates to ongoing processes like learning and memory.

In neurological diseases such as Alzheimer’s and Parkinson’s, there is a loss of neurons and synapses, Biederer said. A better understanding of the ingredients of trans-synaptic signaling could lead to new disease treatments.

“One can speculate that the detrimental effects of these diseases can be balanced by a molecule such as SynCAM that can induce new synapses,” Biederer said. “Other possible applications could include therapies for spinal cord injuries.”

The researchers identified the protein by searching the mouse genome for a candidate molecule that could form a bridge between neurons and recruit synaptic components. A model for synaptic transmission was created by artificially inducing synapses and performing a functional characterization using cultured neurons from laboratory mice. This is the first study in which a model was designed to artificially induce synaptic transmission, Biederer said.

When SynCAM was overexpressed the researchers reported an increase in spontaneous synaptic structures and spontaneous synaptic activity by as much as three-fold. When this function of SynCAM was interrupted, there was a decrease in the number of synapses and activity.

“We are now at the very core of what creates active neuronal networks and a functional central nervous system,” Biederer said.

The researchers are currently studying other proteins that may be involved in this process.

Other researchers involved in the study included Dr. Thomas C. Südhof, senior author of the study, director of the Center for Basic Neuroscience and an investigator in UT Southwestern’s Howard Hughes Medical Institute; Deniz Atasoy, a student research assistant in cell and molecular biology; Drs. Ege Kavalali and Xinran Liu, both assistant professors in the Center for Basic Neuroscience; and Drs. Marina Mozhayeva and Yildirim Sara, both postdoctoral researchers in the Center for Basic Neuroscience.

The study was supported by the National Institutes of Health and the Human Frontier Science Program.



Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map