ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Coconut Oil Healthy? (The American Heart Association Doesn’t Think So)

American Heart Association Renders Itself Obsolete With 1960s Dietary Advice on Coconut Oil

Ginger Fights Obesity

Health Benefits of Artichokes

Putting the Spotlight on Coriander Seed Oil

Migraines? Powdered Ginger May Help

Are Americans Really Getting Too Much Vitamin D? A Critical Look at Recent Media Warnings

Eating more vegetable protein may protect against early menopause

Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer stem cells

German Chamomile Oil: A Versatile Essential Oil You Should Have at Home

 
Print Page
Email Article

Is Fibromyalgia a Central Pain State?

  [ 532 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 3, 2002


Source: Journal: J of Musculoskeletal Pain, Vol. 10, No. 1/2,2002, pp. 45-57
Author: Karl G. Henriksson, MD, PhD
Affiliation: Associate Professor, Department of Rehabilitation Medicine. Pain Clinic and Neuromuscular Unit, Faculty of Health Sciences, Linköping University, Sweden. Address correspondence to: Karl G. Henriksson, MD, PhD, Neuromuscular Unit, University Hospital, Linköping, S-58185 Sweden [E-mail address: mailto:karl-g@telia.com ].

SUMMARY.

Objective: To review the literature concerning pain mechanisms in fibromyalgia [FMS].

Findings and Conclusions: Thirteen investigations using different methods, comprising 250 patients with FMS, confirm a biological dysfunction of the nociceptive system, especially in the central nervous system in the majority of patients with FMS. The hyperexcitability in the nociceptive nervous system may have different causes in the individual patient. Localized long-standing muscle pain, chronic stress, genetic factors, and hormonal changes may all playa role. Pain generators in the muscle may not be specific for FMS but may be of importance for initiating and maintaining pain and allodynia/hyperalgesia.

KEYWORDS. Fibromyalgia, pain mechanisms, muscular pain, central sensitization

INTRODUCTION

According to the classification criteria proposed by the American College of Rheumatology [ACR] fibromyalgia [FMS] comprises one symptom - chronic multifocal pain - and one sign - generalized allodynia/hyperalgesia (]). The patient who is diagnosed with FMS, however, is polysymptomatic. Besides pain there is fatigue, sleep disturbance, psychological distress, impaired muscle function, and symptoms that are usually regarded as stress-related.

Fibromyalgia is an illness, a syndrome, that effects three systems that regulate our well being: the nociceptive system, the stress-regulating system, and the immune system. These systems interact with each other, making it difficult to determine which of them is primarily affected in an individual patient. Psychological factors, personality traits, and social circumstances play a role for the total clinical picture. Fibromyalgia is indeed a biopsychosocial syndrome. The biological part concerns mainly pain and allodynia/hyperalgesia as well as biological changes related to continuous physical and emotional stress. This article will deal only with pain and allodynia. Allodynia is pain elicited by normally nonpainful stimuli. Hyperalgesia is increased pain intensity and prolonged pain duration evoked by stimuli that normally are painful. [ ... ]

CONCLUDING REMARKS

There is strong support for the notion that pain and allodynia/hyperalgesia in FMS have an organic cause. The hyperexcitability in the nociceptive nervous system is mainly due to changes in the CNS. Longstanding excitation of nociceptors and low threshold mechano-receptors in the muscle may initiate and maintain such hyperexcitability. The permanent changes constitute a disease. There are methods for objectively diagnosing this disease.

The psychological and social consequences of chronic pain in FMS are the main determinants for the degree of disability and handicap.

Many causes could initiate and maintain the disease: e.g.,longstanding local or regional musculoskeletal pain, changes in stress-regulating systems, hormonal changes, changes in serotonin metabolisms, and genetic factors.

© 2002 by The Haworth Press, Inc. All rights reserved.



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map