ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

A Little Zinc Goes a Long Way

More evidence for calorie restriction’s longevity effect

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Iron (And More) For Lasting, Natural Energy

Get the Most From Your Green Tea

Affordable Care Act made cancer screening more accessible for millions, study finds

Metabolic syndrome increases the need for vitamin E

 
Print Page
Email Article

Clinical Improvement in Chronic Fatigue Syndrome Associated with Enhanced Natural Killer Cell Mediated Cytotoxicity: The results of a pilot study with Isoprinosine®

  [ 59 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 6, 2002


A. Kumar(1), E. Turgonyi(2), B. Hyde(3), C. Galvis(1), W. Lim(1) and F. Diaz-Mitoma(1)

(1)Departments of Pediatrics, Division of Virology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa; (2)Newport Pharmaceuticals Ltd., Ireland; and (3)Nightingale Research Foundation, Ottawa, Ontario, Canada.

Chronic fatigue syndrome (CFS) is associated with several immune abnormalities, such as decreased natural killer (NK) cell mediated cytotoxicity and dysregulated production of cytokines.

The clinical impact of Isoprinosine® (immunomodulator / antiviral) on various immune functions in a total of 16 CFS patients diagnosed according to the CDC CFS definition was evaluated. Patients were followed for 28 weeks. Clinical improvement based on the clinical staging was observed in 6 out of 10 patients (60%).

CFS patients at baseline compared to normal controls exhibited a significantly decreased NK activity as well as decreased mitogen-induced production of IL-10, IL-12 and IFN-g in PBMC. The clinically improved patients showed a significantly enhanced NK activity [LU(5 and 15% ) / 106 ] which correlated with the duration of the treatment (p<0.03). A significant increase in IL-12 production by T cell mitogen stimulated PBMC was observed in clinically improved patients treated for 28 weeks compared to the patients on placebo (p < 0.02). Treatment with Isoprinosine® for 12 weeks did not appreciably influence the production of IL-1-á and IL-10. However, discontinuation of treatment resulted in enhanced production of both IL-1-á and IL-10 only in clinically improved patients. When treatment was started again at week 16, significantly decreased production of these two cytokines was observed. Treatment with Isoprinosine® for prolonged periods (28 weeks) also resulted in the enhanced number of CD4+ T helper cells and CD4+, HLA-DR+ T cell number in peripheral blood only in clinically improved patients. These results suggest the clinical efficacy of Isoprinosine® and its potential to enhance NK cell activity.

In view of the small number of patients, further studies are required to investigate the contribution of Isoprinosine®-mediated immune effects to the pathogenesis of CFS.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® FibroSleep™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map