ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Hop Oil: A Safe Sleep Aide

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

 
Print Page
Email Article

Antioxidant Reduces Brain Damage in Stroke Model

  [ 22 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 10, 2002


New research shows that a synthetic antioxidant can reduce brain damage by more than 40 percent in an animal model of stroke when given seven and a half hours after the stroke begins. Researchers at National Jewish Medical and Research Center and Duke University Medical Center will report their findings in the October issue of the journal Free Radical Biology and Medicine.

"Because the onset of a stroke can be difficult to detect, many patients do not get treatment for several hours," said James Crapo, M.D., co-author and Chairman of the Department of Medicine at National Jewish. "Our findings suggest that the antioxidant is a promising candidate for stroke therapy because it can prevent damage so many hours after the stroke begins."

Strokes occur when blood supply to the brain is interrupted because blood vessels in the brain either leak or are blocked. Starved of oxygen, the brain cells die. However, cell death continues to occur for many hours, even after blood flow is returned to the brain. Many of the cells that are injured, but not killed by oxygen deprivation, die in the hours following the stroke. Free radicals, highly reactive molecules, kill many of those cells.

The researchers used a synthetic antioxidant, known as AEOL 10150, to neutralize the damaging free radicals and reduce cell death in a mouse model of stroke. AEOL 10150, developed by Dr. Crapo and his colleagues at Duke, mimics the naturally occurring antioxidant superoxide dismutase, but is effective against a wider range of oxygen radicals and lasts longer in the body. Now licensed by Incara Pharmaceuticals Corporation, it has shown promise in preventing damage to cells caused by diabetes and radiation therapy for cancer.

The researchers blocked the middle cerebral artery of rats for 90 minutes. They then injected AEOL 10150 or a placebo into the brains of these mice six hours after the artery had been reopened. The six-hour post-stroke time period has significant clinical relevance. In an unrelated stroke study, 26 percent of patients received treatment within four hours, but 99 percent received treatment within six hours.

When evaluated a week later, animals who received the placebo had an average of 160 cubic millimeters of brain tissue destroyed by the stroke. Animals who received the antioxidant had an average of 92 cubic millimeters of brain tissue destroyed by the stroke, 43 percent less than that the rats who received the placebo.

"There is a significant arc of potentially salvageable tissue surrounding the cells that are killed by the initial stroke," said David S. Warner, M.D., professor of anesthesiology at Duke University Medical Center. "The antioxidant appears to protect this tissue."

The researchers also treated mice with intravenous injections of the antioxidant. Although, this method produced a smaller effect, it reduced both tissue damage and neurological deficit, demonstrating the compound's ability to cross the blood-brain barrier. Mechanistic studies also showed that the antioxidant significantly altered inflammatory gene expression in tissue.



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® Mitochondria Ignite™ with NT Factor®


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map