ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Meta-analysis adds evidence to association between omega-3 supplementation and lower heart rate

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Top Tips to Boost Your Immunity

Vitamin D supplementation could ease IBS symptoms

Essential Oils Lower Blood Pressure

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Print Page
Email Article

FDA Issues Approvable Letter for Lilly's Cymbalta for Treatment of Depression

  [ 280 votes ]   [ Discuss This Article ] • September 17, 2002

From the Makers of Prozac, Cymbalta will Offer New Hope for Those With Depression, When Approved

Eli Lilly and Company (NYSE: LLY) has received an approvable letter from the U.S. Food and Drug Administration (FDA) for CymbaltaTM (duloxetine hydrochloride), a dual reuptake inhibitor that works through two key neurotransmitters - serotonin and norepinephrine - involved in depression.

Approval is contingent upon labeling discussions and resolution of the company's outstanding manufacturing issues.

"Depression affects as many as 340 million people around the world - and over 18 million Americans - each year. Despite the advances in antidepressant therapy that began with the introduction of Prozac® in 1988, often patients fail to benefit from existing therapy. As many as two-thirds of treated patients fail to achieve complete resolution of their symptoms, or remission," said Dr. John Lechleiter, executive vice president of pharmaceutical products and corporate development at Lilly. "The introduction of Cymbalta will offer physicians and patients new hope for this devastating disease."

Lilly submitted its New Drug Application (NDA) for Cymbalta in November 2001 with data from five placebo-controlled depression studies and a one-year open label safety study. Thus far, more than 3,000 patients have taken Cymbalta in clinical trials. Data suggest Cymbalta 60 mg once daily relieves symptoms of depression, such as low mood, anxiety and physical symptoms like aches and pains, as measured by a commonly used depression rating scale1. Study patients who took Cymbalta were up to three times more likely to have complete resolution of their symptoms as patients on placebo.

Cymbalta enhances the levels of two neurotransmitters - serotonin and norepinephrine - while the most commonly used antidepressants, such as Prozac, only affect serotonin. An imbalance of these two neurotransmitters may explain the emotional and physical symptoms depressed patients often endure.

About Eli Lilly and Company

Lilly, a leading innovation-driven corporation, is developing a growing portfolio of best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers - through medicines and information - for some of the world's most urgent medical needs. Additional information about Lilly is available at


1. Hamilton Depression Rating Scale

Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® Ultra EPA  - Fish Oil

Article Comments

Be the first to comment on this article!

Post a Comment

Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Thyroid Health and Fibromyalgia Thyroid Health and Fibromyalgia
Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map