ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Rare Disorder Provides New Insight Into Fighting Infection [Chronic Fatigue Syndrome News]

  [ 63 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 27, 2002


National Institute of Allergy and Infectious Diseases

Through studying a genetic condition known to exist in only two individuals, scientists at the National Institute of Allergy and Infectious Diseases (NIAID) and their colleagues have uncovered new knowledge about the immune system applicable to everyone. The scientists found that an enzyme called caspase-8, known to help trigger apoptosis -- the programmed death of cells -- is also involved in activating many immune system cells to fight off infections. This information, to be published in the September 26 issue of the journal "Nature," potentially could yield a new class of drugs to treat immune system disorders.

"Previously, no one had ever shown that caspase-8 played this other role," says senior study author Michael Lenardo, M.D., of NIAID's Laboratory of Immunology. "Caspase-8 deficiencies might explain why some people don't respond as well as others to vaccines, or why some people's immune systems don't fight off infections as well as others. Caspase-8 may be a useful target for a new class of anti- inflammatory or immunosuppressive therapies."

The NIAID scientists were called on to examine a brother and sister with a puzzling immune system disorder. "These kids were very sick, and their doctors were stymied about the cause of their illness and how to treat it," says Dr. Lenardo. "The doctors referred them to the University of Alabama, and the university in turn referred them to us. We took up the challenge, studied these children for several years, and came up with the answer."

Some of the disorder's symptoms were similar to those of autoimmune lymphoproliferative syndrome (ALPS), which include an overabundance of lymphocytes due to lack of apoptosis, swollen lymph nodes, and an enlarged spleen. ALPS is caused by a defect in the caspase-10 gene. Caspase- 10 is an enzyme that works with caspase-8 to trigger apoptosis. However, genetic tests showed no caspase-10 defects in the siblings.

Instead, the tests revealed a mutation in both copies of the siblings' caspase-8 genes that rendered the caspase-8 enzyme inactive. Furthermore, in addition to their ALPS- like symptoms, the siblings' immune system T cells, B cells, and natural killer cells were not properly activated, causing severe immunodeficiency. The siblings suffered from recurrent viral infections, and they did not respond well to vaccines.

The scientists wondered if all symptoms of this strange disorder -- both the ALPS-like symptoms and the failure of immune system cells to activate -- could be explained by lack of caspase-8. The scientists examined the activity of the caspase-8 enzyme more closely, wondering if this molecule, which had been so firmly established in scientists' minds as a trigger of cell death, could also be instrumental in activating immune system cells to fight off infectious diseases.

Subsequent laboratory tests proved that this is in fact the case. For example, the researchers introduced a functional caspase-8 gene into some of the siblings' lymphocytes and found that the cells recovered their ability to activate in response to stimulation with antigens. Dr. Lenardo and his colleagues plan further study of caspase-8 to determine if deficiencies in this molecule underlie other immune system abnormalities.

Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at .

The National Institute of Allergy and Infectious Diseases is a component of the National Institutes of Health, U.S. Department of Health and Human Services.

Reference: HJ Chun et al. Pleiotropic lymphocyte activation defects due to caspase-8 mutation cause human immunodeficiency. "Nature" 419: 395-99(2002).




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra ATP+, Double Strength Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map