ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Cassia Bark Oil: Why It's Valuable in Traditional Chinese Medicine

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Restoring NAD+ could reduce DNA damage accumulation

 
Print Page
Email Article

Ibuprofen Blocks Aspirin’s Ability to Protect Against Heart Attacks

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 28, 2002




A new study shows the ibuprofen you take to ease arthritis pain can counteract the aspirin that you take to protect your heart. Researchers at the University of Pennsylvania School of Medicine studied how aspirin, when taken to prevent heart attacks, interacts with nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, a common treatment for rheumatoid arthritis. Their findings are published in the December 20th issue of the New England Journal of Medicine.

“Our findings have shown that multiple daily doses of ibuprofen can undermine the cardioprotective effects of a daily aspirin regimen,” said Garret A. FitzGerald, MD, Robinette Professor of Cardiovascular Medicine, chair of the Penn Department of Pharmacology, and director of the Penn Center for Experimental Therapeutics. “NSAIDs and aspirin are two of the most frequently consumed drugs in North America and, since people commonly take both drugs daily, it is important to see how they could interact.”

Much of their concern rests in the fact that aspirin and NSAIDs both inhibit two different versions of the same enzyme, a protein called cyclooxygenase (COX). One variant of the enzyme, COX-1, found in platelets, is essential in creating the molecules that allow platelets to clot blood. The other variant, COX-2, produces the molecules responsible for the pain and inflammation symptomatic of arthritis.

Aspirin will bind to the COX-1 enzyme irreversibly, thereby permanently putting the enzyme and the platelet out of commission. Such a sustained effect on platelets is the key to the ability of aspirin to prevent heart attack and stroke. NSAIDs, however, bind less strongly to a different part of the enzyme, and only impair platelets for a short time. There is no evidence that NSAIDs prevent heart attack or stroke, but their effects on COX-2 help relieve pain and swelling.

“Since both NSAIDs and aspirin both bind near the reactive site deep within the COX-1 enzyme, we thought that NSAIDs might physically block aspirin from reaching its target,” explained Muredach Reilly, MD, a Penn cardiologist and co-author of the study. “It would not do you a lot of good to take one medication only to have another wipe out its effects.”

In particular, the researchers studied the over the counter NSAIDs ibuprofen (e.g. Advil®), diclofenac (Voltaren®) and acetaminophen (e.g. Tylenol®), as well as the prescription NSAID refocoxib (e.g. Vioxx®), which is part of a class of newer, COX-2 specific, NSAIDs. To determine how the drugs might interact, the researchers first studied how the order of dosing might influence the effects of combinations of aspirin with the various NSAIDs on the number of working platelets in volunteers. As they had guessed, taking ibuprofen before aspirin prevented aspirin’s effects on platelet COX-1. If they took aspirin 2 hours before the ibuprofen, however, there was no problem.

They then repeated the study, giving ibuprofen three times a day, the way people would generally take the drug for persistent pain or inflammation. This time they loaded the die against the interaction by giving the aspirin two hours before the morning dose of ibuprofen each day. To their surprise, there was still enough ibuprofen around from the prior evening’s dose to cause the aspirin-blocking interaction.

“We know that aspirin works to protect the heart by acting as a blood thinner, that is, it prevents clotting by inactivating the enzyme that makes platelets stick together,” said FitzGerald. “This study tells us that ibuprofen can prevent this from happening by denying aspirin access to the enzyme’s active site.”

As expected, the researchers failed to see an interaction with rofecoxib, an important point of distinction for patients on aspirin who are making a choice amongst NSAIDs. As a member of the newer COX-2 specific drugs, rofecoxib does not bind to COX-1 in platelets. Perhaps more surprisingly, the interaction was also absent from combinations of aspirin with diclofenac, an older NSAID. The interaction occurs in a narrow channel deep within the COX-1 molecule.

“There is some evidence that diclofenac binds within the enzyme somewhat differently than does ibuprofen, but the failure to interact may also reflect its preference for COX-2, its turnover, or some other factor as yet to be identified,” said FitzGerald.

The researchers also failed to see an interaction with 1000mg of acetaminophen. However, they did find out that at this dose acetaminophen is a weak NSAID. It remains to be seen if higher doses of acetaminophen can exert a full NSAID effect and whether they might effect aspirin like ibuprofen does.

“This study tells us that patients who take ibuprofen, the most common NSAID consumed in North America, are susceptible to an interaction that would undermine the cardioprotective action of low dose aspirin,” said FitzGerald. “Patients taking aspirin to protect against heart attack should seek the advice of their doctors before commencing additional treatments for pain or inflammation.”



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Breaking Through the Mental Fog Breaking Through the Mental Fog
Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall Restoring Gut Health: How to Create a Firewall Against Toxins Entering the Gut Wall
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map