ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

How One Tiny Molecule Turned into One Huge Health Breakthrough

Nutrients Boost Stem Cell Function

Humans have three times more brown body fat

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

How B Vitamins Improve Brain Health, Cognition, Psychiatric Problems and Mood Disorders

Dietary prebiotics improve sleep, buffer impacts of stress, says study

Exercises to Help Prevent Urinary Incontinence

Higher red blood cell omega 3 levels in women linked to lower risk of mortality over 14.9 year media...

 
Print Page
Email Article

High-Dose Cyclophosphamide Promising in Refractory Lupus

  [ 59 votes ]   [ Discuss This Article ]
www.ProHealth.com • January 15, 2003


Laurie Barclay, MD

Jan. 8, 2003 — Refractory systemic lupus erythematosus (SLE) may respond to high-dose cyclophosphamide without stem cell transplantation, according to the results of a small study in the January issue of Arthritis & Rheumatism. A randomized trial is underway.

"There is now great optimism that high-dose cyclophosphamide therapy followed by hematopoietic stem cell transplantation might induce treatment-free remission in a variety of severe autoimmune diseases," write Michelle Petri, MD, and colleagues from Johns Hopkins University in Baltimore, Maryland. "When high-dose cyclophosphamide is used alone, autografting, with its potential for reinfusing autoreactive effector cells, is not required."

Of 14 patients with moderate to severe SLE refractory to steroids plus one or more immunosuppressive drugs, 12 were female, four were African-American, nine had progressive renal lupus, and one had an ulcerating lupus rash covering 60% of her body. Mean age was 35 years.

Treatment consisted of 50 mg/kg cyclophosphamide for four consecutive days followed by 5 µg/kg granulocyte colony-stimulating factor (G-CSF) until the neutrophil count was 1 x 109/L for two consecutive days. Median duration of G-CSF therapy was 14 days (range, 11-22 days). Patients also received supportive care, including packed red blood cell and platelet transfusions.

There were no fungal infections, deaths, mucositis greater than grade 1, or premature ovarian failure. Five patients achieved a durable complete response, as defined by the Responder Index for Lupus Erythematosus, in all involved organ systems including kidney, central nervous system, and skin. Six additional patients had a partial response. Physician's global assessment, SLE Disease Activity Index, and prednisone dosage all improved significantly (P < .0001, P = .0039, and P = .002, respectively).

High-dose cyclophosphamide was well tolerated, with the most common adverse events being nausea, alopecia, transient aplasia, and febrile neutropenia. However, some patients suffered relapses.

"High-dose cyclophosphamide without stem cell transplantation warrants further study in severe autoimmune diseases, including SLE," the authors write. "A randomized trial comparing high-dose cyclophosphamide with the National Institutes of Health monthly IV cyclophosphamide regimen in SLE is already underway."

Arthritis Rheum. 2003;48(1):166-173

Reviewed by Gary D. Vogin, MD



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map