ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

Curcumin Reverses the Cellular Damage of Chronic Stress

Print Page
Email Article

SAM-e Benefits Depression, Osteoarthritis, Liver Disease

  [ 107 votes ]   [ Discuss This Article ] • February 17, 2003

Laurie Barclay, MD (Source: MedScape)

Oct. 15, 2002 — The U.S. Agency for Healthcare Research and Quality (AHRQ), a division of the Department of Health and Human Services, has assembled the evidence available on s-Adenosyl-L-Methionine (SAMe) and has shown actual benefit for the treatment of depression, osteoarthritis, and liver disease.

"The [AHRQ] report indicates that that this is a compound worthy of further investigation," Maurizio Fava, MD, director of the depression clinic and research program at Massachusetts General Hospital in Boston, tells Medscape. "True, these are very small studies, but they consistently suggest the efficacy of this compound in depression."

In treating depression, SAMe is more effective than placebo and as effective as standard antidepressants, with fewer adverse effects. Compared with nonsteroidal anti-inflammatory drugs (NSAIDs), SAMe also relieves the pain of osteoarthritis, but with fewer gastrointestinal adverse effects. It also reduces cholestasis secondary to use of oral contraceptives or estrogen, pregnancy, or birth defects, for which there is currently no other effective treatment.

The AHRQ report reviewed the literature on the use of SAMe in these conditions and identified 294 meta-analyses, clinical trials, and reports, of which 99 articles referencing 102 studies met the screening criteria. Of these 102 studies, most of which enrolled small numbers of patients, 47 focused on depression, 14 focused on osteoarthritis, and 41 focused on liver disease.

In a meta-analysis of 28 studies, treatment with SAMe was associated with an improvement, compared with placebo, of approximately 6 points on the Hamilton Rating Scale for Depression score measured at three weeks (95% confidence interval [CI], 2.2 to 9.0). Compared with conventional antidepressants, treatment with SAMe was not associated with a statistically significant difference in outcomes.

"We've never had a large double-blind study [of SAMe in depression] in the U.S.," Fava says. It's time for researchers to look at this more closely."

Of 13 unique studies considered, 10 studies were included in a meta-analysis of the efficacy of SAMe to decrease the pain of osteoarthritis. In one large randomized clinical trial, SAMe reduced the pain of osteoarthritis by 20% (95% CI, -0.39 to - 0.02) compared with placebo, which was not significantly different from results with NSAIDs.

In a meta-analysis of eight studies of the efficacy of SAMe to relieve pruritus and decrease elevated serum bilirubin levels associated with cholestasis of pregnancy, treatment with SAMe was associated with an effect size compared with placebo of nearly a full standard deviation (-0.95; 95% CI, -1.45 to -0.45) for decrease in pruritus and of over one and one-third standard deviations (-1.32; 95% CI, -1.76 to -0.88) for decrease in serum bilirubin levels.

Two clinical trials which were not pooled favored ursodeoxycholic acid over SAMe for the treatment of pruritus. In a meta-analysis of six studies of the efficacy of SAMe to relieve pruritus and decrease elevated bilirubin levels associated with intrahepatic cholestasis, treatment with SAMe for pruritus was more than twice as likely to reduce pruritus as was placebo (risk ratio 0.45; 95% CI, 0.37 to 0.58).

"A need exists for additional review studies, studies elucidating the pharmacology of SAMe, and clinical trials," the authors write. "A better understanding of the risk benefit ratio of SAMe compared to conventional therapy, especially for depression and osteoarthritis, is very important. To that end, additional analysis of existing data could be done, but it would likely be more productive to support new definitive clinical studies to address this issue."

Sept. 30, 2002

Reviewed by Gary D. Vogin, MD

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Vitamin D3 Extreme™

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Vital Molecule Increases Cellular Energy and Improves Cognitive Function Vital Molecule Increases Cellular Energy and Improves Cognitive Function
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Live Without Anxiety or Stress Live Without Anxiety or Stress

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map