ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Friendly User's Guide for the Timing of Nutritional Supplements

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Mediterranean diet associated with lower risk of aggressive prostate cancer

 
Print Page
Email Article

Abstract: Chronic fatigue syndrome: new evidence for a central fatigue disorder

  [ 733 votes ]   [ Discuss This Article ]
www.ProHealth.com • April 25, 2003


Clin Sci (Lond) 2003 Apr 23; [epub ahead of print]

Georgiades E, Behan WM, Kilduff LP, Hadjicharalambous M, Mackie EE, Wilson J, Ward SA, Pitsiladis YP.

Considerable evidence points towards a prominent role for central neural (CNS) mechanisms in the pathogenesis of chronic fatigue syndrome (CFS), a disorder characterised chiefly by persistent, often debilitating, fatigue.

We wished to characterise circulating profiles of putative amino acid modulators of CNS serotoninergic and dopaminergic function in CFS patients at rest, during symptom-limited exercise and subsequent recovery. Twelve CFS patients and eleven age- and sex-matched sedentary controls, with similar physical activity histories, underwent ramp-incremental exercise to the limit of tolerance.

Plasma amino acid concentrations, oxygen uptake (Vo 2) and ratings of perceived exertion (RPE) were measured at rest, during exercise and recovery. Peak oxygen uptake (Vo 2peak) was significantly lower in the CFS patients, compared to controls. RPE in the patients was higher at all measured time points, including rest, relative to controls. Levels of free tryptophan [free Trp];the rate-limiting serotoninergic precursor, were significantly higher in CFS patients at exhaustion and recovery, whereas concentrations of branched-chain and large-neutral amino acids (BCAA and LNAA, respectively) were lower in patients at exhaustion and, for [LNAA], also during recovery.

Consequently, the [free Trp] : [BCAA] and [free Trp] : [LNAA] ratios were significantly higher in CFS patients, except at rest. On the other hand, levels of tyrosine, the rate-limiting dopaminergic precursor, were significantly lower at all time points in the patients. The significant differences observed in a number of key putative CNS serotoninergic and dopaminergic modulators, coupled with the exacerbated effort perception, provide further evidence for a potentially significant role of CNS mechanisms in CFS pathogenesis.

PMID: 12708966 [PubMed - as supplied by publisher]




Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength FibroSleep™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium

Natural Remedies

Looking for Energy? Turn to Plants. Looking for Energy? Turn to Plants.
Live Without Anxiety or Stress Live Without Anxiety or Stress
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Nutrients to Combat the Modern Stress Epidemic Nutrients to Combat the Modern Stress Epidemic
How Glutathione Can Save Your Life How Glutathione Can Save Your Life

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map