ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Central Nociceptive Hyperexcitability Important in Fibromyalgia

  [ 550 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 19, 2003


By Laurie Barclay, M.D.

Central nociceptive hyperexcitability may be important in fibromyalgia (FM), according to the results of a study published in the May issue of Arthritis & Rheumatism. The nociceptive flexion reflex may be helpful in discriminating which patients would benefit from central analgesia.

"Our results strongly, although indirectly, point to a state of central hyperexcitability of the body's central pain system in patients with FM," lead author J. A. Desmeules, M.D., from Geneva University Hospital in Switzerland, says in a news release.

Of 85 outpatients with FM attending a self-management program, 89% were women, all were middle-aged, and mean disease duration was eight years.

Compared with 40 healthy controls matched for age and sex, peripheral quantitative sensory testing in FM patients showed significantly altered cold and heat pain thresholds, with tolerance to cold pain 66% lower. Threshold for the spinal nociceptive flexion reflex was 50% lower than in controls.

Using a cutoff value of less than 27.6 mA for nociceptive flexion reflex, sensitivity was 73% and specificity was 80% for detecting central allodynia.

According to Dr. Desmeules, these findings suggest the benefits of treating FM with analgesics acting on the central nervous system. Antidepressants have been shown to reduce the pain sensitivity reflex of healthy volunteers after a single dose.

"The nociceptive flexion reflex can be used to assess central allodynia in patients with FM," the authors write, while recommending additional research. "It may also help discriminate patients who may benefit from use of centrally acting analgesics."

Study Reference: Arthritis Rheum. 2003;48:1420-1429

Reviewed for WebMD by Gary D. Vogin, M.D.



Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Breaking Through the Mental Fog Breaking Through the Mental Fog
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Secret Nutrient for Radiant Skin Secret Nutrient for Radiant Skin
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map