ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Health Benefits of Manuka Honey

Increase Your Magnesium Intake

Vitamin D supplementation could ease IBS symptoms

Top Tips to Boost Your Immunity

11 Amazing Health Benefits of Using Baking Soda

Nicotinamide riboside shows promise for treatment of Alzheimer’s disease

Exercise, calcium, vitamin D, and other factors linked with fewer injurious falls

Vitamin D3 Is a Powerhouse for Your Heart

Rhodiola — A Powerful Adaptogen That Boosts Vitality and Performance, Eases Depression and Combats B...

Curcumin Supplementation May Impart Long-Term Cognitive Benefits

 
Print Page
Email Article

Central Nociceptive Hyperexcitability Important in Fibromyalgia

  [ 550 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 19, 2003


By Laurie Barclay, M.D.

Central nociceptive hyperexcitability may be important in fibromyalgia (FM), according to the results of a study published in the May issue of Arthritis & Rheumatism. The nociceptive flexion reflex may be helpful in discriminating which patients would benefit from central analgesia.

"Our results strongly, although indirectly, point to a state of central hyperexcitability of the body's central pain system in patients with FM," lead author J. A. Desmeules, M.D., from Geneva University Hospital in Switzerland, says in a news release.

Of 85 outpatients with FM attending a self-management program, 89% were women, all were middle-aged, and mean disease duration was eight years.

Compared with 40 healthy controls matched for age and sex, peripheral quantitative sensory testing in FM patients showed significantly altered cold and heat pain thresholds, with tolerance to cold pain 66% lower. Threshold for the spinal nociceptive flexion reflex was 50% lower than in controls.

Using a cutoff value of less than 27.6 mA for nociceptive flexion reflex, sensitivity was 73% and specificity was 80% for detecting central allodynia.

According to Dr. Desmeules, these findings suggest the benefits of treating FM with analgesics acting on the central nervous system. Antidepressants have been shown to reduce the pain sensitivity reflex of healthy volunteers after a single dose.

"The nociceptive flexion reflex can be used to assess central allodynia in patients with FM," the authors write, while recommending additional research. "It may also help discriminate patients who may benefit from use of centrally acting analgesics."

Study Reference: Arthritis Rheum. 2003;48:1420-1429

Reviewed for WebMD by Gary D. Vogin, M.D.



Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ FibroSleep™ Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get Energized with Malic Acid & Magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2018 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map