ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

Probiotics improve cognition in Alzheimer's patients

The Onion: Cancer Fighter and Food Preserver

SURVEY RESULTS: Cognitive Impairment II

 
Print Page
Email Article

Yeast Genomes Reveal New Sites of Gene Control

  [ 44 votes ]   [ Discuss This Article ]
www.ProHealth.com • May 30, 2003


Researchers at Washington University School of Medicine in St. Louis have begun unraveling the network of genes and proteins that regulate the lives of cells. The investigators compared the genome of the yeast Saccharomyces cerevisiae (S. cerevisiae) to those of five other yeast species to identify all the locations at which molecules known as regulatory proteins attach to DNA to turn genes on and off. The study is published in the May 30 issue of the journal Science.

Among the many potential sites of gene regulation, 79 were predicted to be definitive new regulatory sites. The investigators also discovered 43 new genes and determined that 515 suspected genes are not genes at all. The findings revised the estimated number of genes in the S. cerevisiae genome from 6,331 to 5,773.

"This is the first step in understanding the gene-regulation network in a simple cell," says principal investigator Mark Johnston, Ph.D., professor of genetics and interim chair of genetics. "This work also will provide guidelines for analyzing the regulatory network of human cells, which will be a much more complex task."

Regulatory sequences are important, Johnston notes, because they are the basis of development. For example, a liver cell differs from a brain cell not because they have different genes—both cells have the same set of genes—but because of the genes they use. And that’s determined by the regulatory sequences that activate one set of genes in the liver and another set in the brain. A variety of diseases, including cancer, are caused by problems in gene regulation.

Identifying gene regulatory sites is not easy, however. These regions serve as docking sites for DNA binding proteins that turn the gene on or off. They lack the typical DNA patterns that help scientists recognize the body of the gene, which contains information about the structure of a protein.

Johnston and his colleagues compared the genomes of S. cerevisiae to five other yeast species, hypothesizing that the regions that were most alike in all six would be potential regulatory sites.

The investigators found about 8,000 of these conserved sites, about one-third of which already were known regulatory sequences. After eliminating the known sites from the total, the investigators searched for other evidence that these sites are functional, and pinpointed 79 sites located within or near genes which are excellent candidates for new regulatory sequences.

The team will is now refining the number of sites by determining which yeast regulatory proteins bind to the them. "Now," Johnston says, "we can begin tackling the really interesting question: how a relatively small number of regulatory proteins coordinate the activity of more than 5,700 genes to maintain a healthy, growing yeast cell."

Cliften P, Sudarsanam P, Desikan A, Fulton L, Fulton B, Majors J, Waterston R, Cohen BA, Johnston M. Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science, May 30, 2003. Funding from the National Institute of General Sciences supported this research.



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Ultra EPA  - Fish Oil Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map