ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fight Back! Win the War Being Waged Against Your Immune System

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

The role of microbiota and intestinal permeability in the pathophysiology of autoimmune and neuroimm...

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Acupressure reduced fatigue in breast cancer survivors

Omega-3 fatty acid stops known trigger of lupus

What’s Fenugreek Good For?

Print Page
Email Article

Levels of 'Anti-Pain' Brain Chemicals Vary Among People - Fibromyalgia News

  [ 46 votes ]   [ Discuss This Article ] • July 1, 2003

Source: Scientific American (July 2001)

For the first time, researchers have examined in real time how different people feel pain in the brain. By monitoring healthy humans experiencing sustained pain, scientists at the University of Michigan got to watch the brain's painkiller system in action and determined that not all brains handle pain equally well. Their results appear in today's issue (July 13, 2001) of the journal Science.

Thirteen men and seven women volunteered to undergo 20 minutes of constant pain, caused by an injection of highly-concentrated salt water into their jaw muscles. While they suffered, the scientists took brain scans using positron emission tomography (PET). The subjects also received a 20-minute injection of a placebo solution in the randomized, double-blind study. Patients recorded the level of pain they felt every 15 seconds during the injections and completed a pain questionnaire about their experience at the end of the experiment.

Using a small amount of a radioactive substance as a tracer, the scientists focused on the brain's mu-opioid system in which chemicals called endogenous opioids bind to receptors and hinder the spread of pain messages in the brain. The researchers saw the greatest change in brain regions involved in emotional responses and those responsible for processing sensations. They controlled the experimental conditions so that the subjects experienced similar levels of pain, but found that individuals showed different patterns of mu-opioid activity.

There were differences in both the amount of chemicals released and the timing of the release. As it turned out, subjects who experienced the largest change in the mu-opioid system between the placebo injection and the painful one tended to report the least pain.

"This may help explain why some people are more sensitive, or less sensitive, than others when it comes to painful sensations," lead author Jon-Kar Zubieta says. "We show that people vary both in the number of receptors that they have for these anti-pain brain chemicals, and in their ability to release the anti-pain chemicals themselves." The scientists hope the study's results will be helpful in understanding and perhaps treating persistent pain syndromes. "It may also be quite relevant," Zubieta says, "to why some people, but not others, develop chronic pain conditions."

--Sarah Graham

Visit Scientfic American's website:

Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil FibroSleep™ Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
How to Jump-start and Sustain Energy Production in CFS How to Jump-start and Sustain Energy Production in CFS
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map