ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Dr. Charles Shepherd on the Similarities Between Primary Biliary Cirrhosis and Chronic Fatigue Syndrome

  [ 191 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 9, 2003


By Dr. Charles Shepherd

There is a very good review of the illness known as primary biliary cirrhosis (PBC) in a recent edition [July 2003] of The Lancet medical journal.

As PBC has a number of important similarities to ME/CFS, and occasionally gets misdiagnosed as ME/CFS, I will run through some key points:

1. The two most common symptoms of PBC are chronic fatigue and itching of the skin (pruritis). Despite PBC being a potentially serious liver disease, jaundice is unusual and only tends to occur once it has become severe.

2. PBC tends to affect middle aged females.

3. Although the cause is unknown, genetic factors and immune system dysregulation are involved. There is also evidence of hormonal dysfunction, in particular impaired corticotropin-releasing hormone activity (as in ME/CFS).

4. Suspicions about a diagnosis of PBC should be raised in anyone who has chronic fatigue and abnormal liver function tests (as can obviously occur in ME/CFS) - especially if there is a rise in the level of a liver chemical called alkaline phosphatase (2-10 times upper limit of normal). Modestly raised levels of liver enzymes also occur.

5. Evidence of immune system dysfunction comes from the presence of autoantibodies (again as can happen in ME/CFS), especially antimitochondrial antibodies (titres greater than 1/40). And an autoimmune rheumatic disorder called Sjogren's syndrome is more common in people with PBC (as it is with ME/CFS).

6. The fatigue part of PBC is particularly interesting in that it has similar qualities to that seen in ME/CFS, and in the case of PBC it has been shown to be independent of the severity of the liver disease, sleep disturbance or depression (further similarities with ME/CFS).

So it seems that PBC fatigue may be related to abnormalities in brain chemical transmitters (possibly good old serotonin) and it's interesting to note that one small study (ref: Lancet, 1999, 354, 397) has shown that a drug called ondansetron/Zofran can significantly reduce PBC fatigue. There is also a report from Germany suggesting that this drug could be of benefit in ME/CFS (ref: Scandinavian Journal of Rheumatology, 2000, 29, suppl 113, 72-77).

7. Making a correct diagnosis of PBC as early as possible is important because effective treatment with a drug called ursodeoxycholic acid will halt the progression of the disease and reduce the need for a possible liver transplant later on.

Source: 'Primary biliary cirrhosis', Lancet, 2003, 362, 53 - 61.

More information on PBC and ME/CFS can be found in Dr. Charles Shepherd's book, "Living with ME" on page 96. To purchase this book from amazon.com, click on the following link: http://www.amazon.com/exec/obidos/tg/detail/-/0091816793/qid=1057691914/sr=1-1/ref=sr_1_1/104-2012199-1654354?v=glance&s=books



Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Optimized Curcumin Longvida® Energy NADH™ 12.5mg


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS The Crucial Role CoQ10 Plays in Fibromyalgia and ME/CFS
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map