ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Relief for IBS, Colitis, Crohn’s And More

B Vitamins May Protect Against Damaging Effects of Air Pollution, and Improve Cognition and Psychiat...

Restless Leg Syndrome (RLS) - are you running a marathon each night?

Can Magnesium Relieve Your Tinnitus?

Resveratrol Proven to Slow Brain Aging

Magnesium Protects Against Stroke, Heart Disease and Diabetes

Fruits and vegetables' latest superpower? Lowering blood pressure

Neroli Oil: The Pleasantly Fragrant Citrus Oil

Prenatal vitamin D could help prevent autism in children

Restoring NAD+ could reduce DNA damage accumulation

Print Page
Email Article

Setting the Stage for Illness: Mercury Exposure and Autoimmune Disease

  [ 124 votes ]   [ Discuss This Article ] • August 20, 2003

By Ernie Hood

Source: Environmental Health Perspectives Volume 111, Number 10, August 2003

The current scientific literature abounds with studies of the strongly suspected link between exposure to inorganic mercury (iHg) and autoimmune disease, a family of often debilitating and sometimes fatal conditions. Although no human association has been documented, the connection is well known in animal models.

A great deal of work continues to characterize the complex physiologic mechanisms involved and thereby shed light on the role of environmental mercury exposures in the etiology of these illnesses. Now a team of Maryland investigators has found that even brief, low-level environmental mercury exposure may increase susceptibility to autoimmune disease in mice [EHP 111:1273-1277].

iHg experiments often use mice bred for susceptibility to various autoimmune diseases. In this study, however, the team used healthy, genetically nonsusceptible mice. The researchers injected treatment groups of 6- to 8-week-old female B6D2F1 mice with iHg doses of 20 or 200 micrograms per kilogram dissolved in water. The mice were dosed every other day for 15 days, for a total of 8 doses. Control animals were injected with an equal total volume of sodium chloride. Five days after cessation of the iHg injections, both case and control mice were intravenously administered spleen cells from another mouse strain to induce chronic graft-versus-host disease (GVHD), a well-established murine model of acquired autoimmunity.

This study involved very low exposures compared to those commonly used in studies of iHg immunotoxicity (typically 500-2,000 micrograms per kilogram). These low doses helped avoid confounding of the subsequent results by the toxic effects of iHg exposure itself or by directly causing iHg-associated autoimmune disease.

The dose of parental donor cells was set just above the threshold for consistent induction of chronic GVHD, and under normal conditions would be expected to induce a mild case of the lupus like condition, as it did in the controls. In the case mice, however, the scientists determined that the iHg pretreatment clearly accelerated and exacerbated the course of the disease.

Unlike the control mice, the iHg-exposed mice experienced glomerulonephritis (an inflammatory kidney disease) and elevated urine protein, evidence of accelerated GVHD. The glomerulonephritis, in turn, resulted in accelerated mortality in the iHg-treated groups. Upon reexamination 2-3 months after disease induction, autoantibodies characteristic of chronic GVHD were found to have become significantly elevated in surviving iHg-treated mice, but no markers characteristic of iHg-associated autoimmunity were seen. These results imply that the iHg treatment affected the acquired autoimmune disease itself--that the disease was not caused by delayed effects of the iHg exposure, but that its course was worsened by the exposure.

The results of the study, the first of its kind, support the hypothesis that low-level environmental exposure to mercury is a potential factor in the development of autoimmune disease in humans.

Disturbingly, these results further suggest that "low-level exposure . . . may lower the threshold for disease development in susceptible individuals who later encounter the appropriate infectious or toxic triggers of disease." If these findings are confirmed by replication and further research, the implications regarding safe thresholds for environmental mercury exposure could be profound.


Low-Dose Exposure to Inorganic Mercury Accelerates Disease and Mortality in Acquired Murine Lupus

Charles S. Via,1,2 Phuong Nguyen,1,2 Florin Niculescu,1,2 John Papadimitriou,3 Dennis Hoover,4 and Ellen K. Silbergeld4
1Research Service, Department of Veteran Affairs Medical Center, Baltimore, Maryland, USA; 2Division of Rheumatology and Clinical Immunology, and 3Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA; 4Bloomberg School of Public Health, Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland, USA


Inorganic mercury (iHg) is known to induce autoimmune disease in susceptible rodent strains. Additionally, in inbred strains of mice prone to autoimmune disease, iHg can accelerate and exacerbate disease manifestations. Despite these well-known links between iHg and autoimmunity in animal models, no association between iHg alone and autoimmune disease in humans has been documented. However, it is possible that low-level iHg exposure can interact with disease triggers to enhance disease expression or susceptibility.

To address whether exposure to iHg can alter the course of subsequent acquired autoimmune disease, we used a murine model of acquired autoimmunity, lupus-like chronic graft-versus-host disease (GVHD), in which autoimmunity is induced using normal, nonautoimmune prone donor and F1 recipient mice resistant to Hg-induced autoimmunity.

Our results indicate that a 2-week exposure to low-dose iHg (20 or 200 µg/kg every other day) to donor and host mice ending 1 week before GVHD induction can significantly worsen parameters of disease severity, resulting in premature mortality. iHg pretreatment clearly worsened chronic lupus-like disease, rather than GVHD worsening iHg immunotoxicity.

These results are consistent with the hypothesis that low-level, nontoxic iHg preexposure may interact with other risk factors, genetic or acquired, to promote subsequent autoimmune disease development. Key words: autoimmunity, glomerulonephritis, graft-versus-host disease, lupus, mercury, T cells.

Environ Health Perspect 111:1273-1277 (2003). doi:10.1289/ehp.6064 available via [Online 1 April 2003]

Address correspondence to C.S. Via, Division of Rheumatology, MSTF 8-34, 10 S. Pine St., Baltimore, MD 21201 USA. Telephone: (410) 706-6474. Fax: (410) 706-3205. E-mail:

This work was supported by National Institutes of Health grant RO1 AI47466 (C.S.V.), Department of Veterans Affairs Merit Review grant (C.S.V.), and a grant from the Heinz Family Foundation (E.K.S.). F.N. is a recipient of an Engelicheff Fellowship Award from the Maryland chapter of the Arthritis Foundation.

The authors declare they have no conflict of interest.
Received 16 October 2002; accepted 1 April 2003.

Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

NAD+ Ignite with Niagen

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
How One Tiny Molecule Turned into One Huge Health Breakthrough How One Tiny Molecule Turned into One Huge Health Breakthrough
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map