ProHealth lyme Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Chronic Pain, Loneliness, Depression and Suicide

TOUCHED BY LYME: An intriguing short film about Lyme disease

Rebuilding Collagen in Lyme Disease

Things to Do When You're Mostly Housebound

Four Tips to Survive a Lyme Disease Setback

Is a Good Night's Sleep at the Top of Your Wishlist?

When Everybody has a Plan in Life Except You

The Restorative Power of Nature

Antibiotics for the neurological complications of Lyme disease

VIDEO: Dear Healthy People: Identity Crisis

 
Print Page
Email Article

Andrographis Useful for the Treatment of Inflammatory Diseases

  [ 1 vote ]   [ Discuss This Article ]
By S. Gupta, et al. • www.ProHealth.com • November 8, 2017


Editor’s Note: Andrographis and its main medicinal component, andrographolide, have been found to have powerful antimicrobial and anti-inflammatory effects in Lyme disease. Andrographis is discussed at length in Steven Harrod Buhner’s book, Healing Lyme.
 
Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis
 
Abstract
 
Andrographolide, a diterpenoid lactone obtained from plant Andrographis paniculata, is used in South Asian countries to relieve various inflammatory symptoms. To study the effects of this agent, the impact of andrographolide on production of inflammatory mediators were delineated in mouse peritoneal macrophages (PM?). Inflammatory mediators like nitric oxide (NO), tumor necrosis factor (TNF)-?, interleukin-6 and related molecular mechanisms of andrographolide-mediated inhibition of enzymes/transcription factors were studied.
 
In addition, the in vivo anti-inflammatory activity of andrographolide was evaluated in an adjuvant-induced arthritis rat model. The results indicated that andrographolide clearly inhibited the production of NO and TNF-? in lipopolysaccharide-activated PM? in a dose-related manner. Immunoblot analyses revealed that andrographolide suppressed activation of both inducible NO synthase and cyclo-oxygenase-2 by directly targeting nuclear transcription factor (NF)-?B.
 
Complete Freund's Adjuvant-induced paw edema in rats was also significantly inhibited by andrographolide treatment. From the data, we concluded that andrographolide imparted anti-inflammatory effects by suppressing two key inflammatory enzymes and a signaling pathway that mediates expression of variety of inflammatory cytokines/agents in situ. It is plausible that eventually, after further toxicologic characterization, andrographolide might be useful as a drug for the clinical treatment of various inflammatory diseases like rheumatoid arthritis or diseases associated with joint pain.
 
Source: By Gupta S1, Mishra KP2, Singh SB1, Ganju L1. Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis.
Inflammopharmacology. 2017 Jul 22. doi: 10.1007/s10787-017-0375-7. [Epub ahead of print]
 



Post a Comment

Featured Products From the ProHealth Store
Omega 3-6-9 Pro-C Complex™ Vitamin D3 5000 IU


Article Comments



Be the first to comment on this article!

Post a Comment


 
Optimized Curcumin Longvida with Omega-3

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Pro-C Complex™ Pro-C Complex™
Buffered Vitamin C for Enhanced Absorption
Ubiquinol CoQ-10 Ubiquinol CoQ-10
Reduced, Active Form of CoQ10
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The Super Antioxidant for Brain, Joint and Heart Health The Super Antioxidant for Brain, Joint and Heart Health
Supercharge Your Brain with Two Powerful Nutrients Supercharge Your Brain with Two Powerful Nutrients
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map