ProHealth me-cfs Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Crash and Flare Busters for ME/CFS and Fibromyalgia

Letter to My Chronic Illness

Surviving the Holidays with Chronic Fatigue Syndrome and Fibromyalgia. How Do You Do It?

The Brain Initiative: A Boon for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?

Setting Goals When You Are Chronically Ill

VIDEO: Powerful Proof that Symptoms of Chronic Fatigue Syndrome and Fibromyalgia are REAL and MAINLY...

Is Chronic Fatigue Syndrome (ME/CFS) a Brain Disease? The 2016 IACFS/ME Conference Pt. III

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Recovery Potentially Possible: Naviaux Talks on Chronic Fatigue Syndrome (ME/CFS)

The Great NIH Exercise Initiative: A Boon for Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia?

 
Print Page
Email Article

Evidence that immune decline with age is function of oxidative stress

  [ 12 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 19, 2012


Free radicals (coupled with cells' decreased production of antioxidant enzymes) cause buildup of damaged proteins that can be toxic to immune cells

Researchers at Albert Einstein College of Medicine of Yeshiva University have uncovered one of the mechanisms by which aging may compromise the ability of the immune system to fight infections and respond to vaccines.

The study, conducted in aging mice, shows that administering antioxidants may help reverse this loss of immune function. (The findings were published online July 13 by Cell Reports.)

"Aging is known to affect immune function, a phenomenon known as immunosenescence, but how this happens is not clear," said study leader Laura Santambrogio, MD, PhD, associate professor of pathology and microbiology & immunology at Einstein. "Our study has uncovered several ways in which aging can worsen the body's overall ability to mount an effective immune response."

• All cells generate chemicals called free radicals as a normal part of metabolism.

• These highly reactive, unstable molecules can readily damage proteins, lipids and other cellular components through oxidation (the reaction between oxygen and substances it comes in contact with – as with rust formation on a tin can).

• Healthy cells keep "oxidative stress" in check by producing several enzymes that are scavengers of free radicals.

• But in aging, increased production of free radicals - coupled with cells' decreased production of antioxidant enzymes - causes a buildup of damaged proteins and other molecules that can be toxic to cells.

Protecting Dendritic Cells – the Immune Alarm System

The current study is the first to examine whether age-related oxidative stress compromises the function of a type of immune cell called dendritic cells.

"Dendritic cells are known as the 'sentinels of the immune system' and alert the rest of the immune system to the presence of microbial invaders," Dr. Santambrogio explains. "When you are exposed to viruses or bacteria, these cells engulf the pathogens and present them to the immune system, saying in effect, 'There's an infection going on, and here is the culprit - go get it.'"

Dr. Santambrogio and colleagues isolated dendritic cells from aging mice and found that oxidation-damaged proteins had accumulated in those cells and had caused harmful effects. For example, oxidatively modified proteins hampered the function of endosomes, the organelle on dentritic cells where pathogens are inactivated.

When the mice were injected with a potent antioxidant in the abdominal cavity daily for two weeks, some of the effects of oxidative stress were reversed.

This finding has implications for designing vaccines or therapies for humans, especially the elderly, whose weakened immune systems increase their susceptibility to infections and cancer, and reduce vaccine effectiveness.

"Many elderly people respond very poorly to vaccination, so perhaps a cycle of therapy with antioxidants before vaccination might improve their immune response to vaccines," Dr. Santambrogio notes.

Source: Based on Cell Reports journal press release, Jul 17, 2012




Post a Comment

Featured Products From the ProHealth Store
Hydroxocobalamin Extreme™ Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
MitoQ® MitoQ®
Powerful Antioxidant Support to Mitochondria
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health
Bone Broth Benefits for Digestion, Arthritis and Cellulite Bone Broth Benefits for Digestion, Arthritis and Cellulite
Eating Fat is Good... Maybe... Could Be... Sometimes Eating Fat is Good... Maybe... Could Be... Sometimes
Safely Burn Away Body Fat Safely Burn Away Body Fat
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map